Identification of Prognostic Genes and Pathways in Lung Adenocarcinoma Using a Bayesian Approach.
Identification of Prognostic Genes and Pathways in Lung Adenocarcinoma Using a Bayesian Approach.
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DOI：
10.1177/1176935116684825
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发表时间：
2017
影响因子：
2
通讯作者：
Wu C
中科院分区：
文献类型：
--
作者：
Jiang Y;Huang Y;Du Y;Zhao Y;Ren J;Ma S;Wu C
肺癌是美国和世界上癌症相关死亡的主要原因。腺癌是肺癌最常见的亚型，通常在晚期诊断，预后较差。过去，人们一直致力于阐明肺癌的发病机制和确定与生存结果相关的基因。由于肺癌的进展是一个复杂的过程，涉及来自癌症相关途径的功能相关基因的协调作用，因此对同时识别预后途径和这些途径中的重要基因的兴趣越来越大。在这项研究中，我们使用贝叶斯方法分析了癌症基因组图谱肺腺癌数据，该方法结合了途径信息以及基因之间的相互联系。研究发现，前11条通路在肺腺癌预后中发挥重要作用，包括丝裂原激活的蛋白激酶信号通路、细胞因子-细胞因子受体相互作用通路和泛素介导的蛋白水解途径。我们还找到了关键的基因特征，如RELB、MAP4K1和UBE2C。这些结果表明，贝叶斯方法可能有助于发现与肺腺癌患者生存密切相关的重要基因和途径。
Lung cancer is the leading cause of cancer-associated mortality in the United States and the world. Adenocarcinoma, the most common subtype of lung cancer, is generally diagnosed at the late stage with poor prognosis. In the past, extensive effort has been devoted to elucidating lung cancer pathogenesis and pinpointing genes associated with survival outcomes. As the progression of lung cancer is a complex process that involves coordinated actions of functionally associated genes from cancer-related pathways, there is a growing interest in simultaneous identification of both prognostic pathways and important genes within those pathways. In this study, we analyse The Cancer Genome Atlas lung adenocarcinoma data using a Bayesian approach incorporating the pathway information as well as the interconnections among genes. The top 11 pathways have been found to play significant roles in lung adenocarcinoma prognosis, including pathways in mitogen-activated protein kinase signalling, cytokine-cytokine receptor interaction, and ubiquitin-mediated proteolysis. We have also located key gene signatures such as RELB, MAP4K1, and UBE2C. These results indicate that the Bayesian approach may facilitate discovery of important genes and pathways that are tightly associated with the survival of patients with lung adenocarcinoma.