The influence of post-nerve injury survival duration on receptive field size: Location, location, location
The influence of post-nerve injury survival duration on receptive field size: Location, location, location
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DOI：
10.1016/j.neulet.2006.06.022
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发表时间：
2006-09-11
影响因子：
2.5
通讯作者：
Garraghty, Preston E.
中科院分区：
文献类型：
--
作者：
Churchill, James D.;Garraghty, Preston E.
在本研究中，我们研究了上行体感神经轴多个水平的损伤后存活时间与感受野大小之间的关系。在实验中的幼稚受试者中，无毛手上的感受野通常仅限于个位数。然而，在目标神经切片之后，感受野通常跨越多个手指。在这些实验中，成年松鼠猴接受了正中神经和尺神经的成对横断，并在进行最终电生理记录之前允许其存活不同时期（2-28个月）。在脑干、丘脑和皮层区域中评估皮肤激活的多指感受野的频率，这些区域通常专用于（现在）部分传入神经缺失的手。我们报告说，对于初级体感皮层的 3b 区域，感受野大小随着生存时间的变化而变小。相比之下，生存时间对脑干楔形核或丘脑腹后外侧核的多指感受野频率没有明显影响。这些观察结果表明，负责细化感受野的机制主要存在于皮质中。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
In the present study, we examined the relationship between post-injury survival duration and receptive field size at multiple levels of the ascending somatosensory neuroaxis. In experimentally naive subjects, receptive fields on the glabrous hand are typically restricted to single digits. Yet, following targeted nerve section, receptive fields often span multiple digits. In these experiments, adult squirrel monkeys were subject to paired transections of the median and ulnar nerves and permitted to survive for varying periods (2-28 months) prior to terminal electrophysiological recording. The frequency of cutaneously activated multiple-digit receptive fields was evaluated in regions of brainstem, thalamus and cortex normally devoted to the (now) partially deafferented hand. We report that for area 3b of primary somatosensory cortex, receptive field size became smaller as a function of survival duration. In contrast, survival duration had no appreciable effect on the frequency of multiple-digit receptive fields in either the cuneate nucleus of the brainstem or the ventroposterior lateral nucleus of the thalamus. These observations suggest that the mechanisms responsible for the refinement of receptive fields are, primarily, resident to the cortex. (c) 2006 Elsevier Ireland Ltd. All rights reserved.