Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment
Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment
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DOI：
10.1016/j.canlet.2018.01.037
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发表时间：
2018-04-01
期刊：
影响因子：
9.7
通讯作者：
Li, Tao-Sheng
中科院分区：
文献类型：
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作者：
Yan, Chen;Luo, Lan;Li, Tao-Sheng
癌症患者的放射治疗会损伤正常组织，从而诱导炎症反应并促进癌症转移。我们研究了具有辐射防护和抗炎特性的化合物尼卡地文（nicaraven）是否可以减弱辐射诱导的小鼠肺部癌症转移。Nicaraven和amifostine，另一种商业辐射防护剂，在体外对刘易斯肺癌细胞的辐射敏感性和在体内辐射诱导的肿瘤生长抑制作用有限。使用实验和自发转移模型，我们证实，胸部照射与5戈伊X射线显着增加了肿瘤的数量在肺部。有趣的是，在放射暴露后，通过给予尼卡地文而不是每天给予氨磷汀，肺中的肿瘤数量显著减少。此外，nicaraven管理有效地抑制CCL8的表达和巨噬细胞募集在肺部照射后1天。我们的数据表明，尼卡地文减弱辐射诱导的肺转移，可能是通过调节辐射暴露后的炎症反应。(C)2018 Elsevier B.V.版权所有。
Radiotherapy for cancer patients damages normal tissues, thereby inducing an inflammatory response and promoting cancer metastasis. We investigated whether nicaraven, a compound with radioprotective and anti-inflammatory properties, could attenuate radiation-induced cancer metastasis to the lungs of mice. Nicaraven and amifostine, another commercial radioprotective agent, had limited effects on both the radiosensitivity of Lewis lung carcinoma cells in vitro and radiation-induced tumor growth inhibition in vivo. Using experimental and spontaneous metastasis models, we confirmed that thorax irradiation with 5 Gy X-rays dramatically increased the number of tumors in the lungs. Interestingly, the number of tumors in the lungs was significantly reduced by administering nicaraven but not by administering amifostine daily after radiation exposure. Furthermore, nicaraven administration effectively inhibited CCL8 expression and macrophage recruitment in the lungs 1 day after thorax irradiation. Our data suggest that nicaraven attenuates radiation-induced lung metastasis, likely by regulating the inflammatory response after radiation exposure. (C) 2018 Elsevier B.V. All rights reserved.