Closed-loop bioelectronic medicine for diabetes management.
Closed-loop bioelectronic medicine for diabetes management.
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DOI：
10.1186/s42234-020-00046-4
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发表时间：
2020-01-01
影响因子：
--
通讯作者：
Georgiou, Pantelis
中科院分区：
文献类型：
--
作者：
Guemes Gonzalez, Amparo;Etienne-Cummings, Ralph;Georgiou, Pantelis
通过输送电气或药物制剂来调节神经系统，有助于开发治疗严重健康疾病的新疗法。多学科研究的最新进展使一种新的强大的治疗方法--生物电子医学的出现成为可能。生物电子医学利用了这样一个事实，即我们体内的每个器官都受到神经支配，因此与周围神经的电连接可能是诊断或治疗糖尿病等疾病的潜在途径。在这种背景下，大量的研究证实了神经系统在维持葡萄糖稳态的严格调节中的重要作用。这启动了新的研究，探索生物电子药物改善糖尿病患者血糖控制的机会，包括调节胃排空、胰岛素敏感性和胰腺激素的分泌。此外，新的闭环策略的开发旨在提供与神经系统的有效、特定和安全的接口，从而针对感兴趣的器官。这在糖尿病等慢性疾病的背景下尤其有价值，在这种情况下，闭环生物电子医学有望提供实时、自主和针对患者的治疗。在这篇文章中，我们概述了与糖尿病相关的闭环神经调节系统的最新进展，并讨论了未来治疗这一慢性疾病的相关机会。
Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary research has enabled the emergence of a new powerful therapeutic approach called bioelectronic medicine. Bioelectronic medicine exploits the fact that every organ in our bodies is neurally innervated and thus electrical interfacing with peripheral nerves can be a potential pathway for diagnosing or treating diseases such as diabetes. In this context, a plethora of studies have confirmed the important role of the nervous system in maintaining a tight regulation of glucose homeostasis. This has initiated new research exploring the opportunities of bioelectronic medicine for improving glucose control in people with diabetes, including regulation of gastric emptying, insulin sensitivity, and secretion of pancreatic hormones. Moreover, the development of novel closed-loop strategies aims to provide effective, specific and safe interfacing with the nervous system, and thereby targeting the organ of interest. This is especially valuable in the context of chronic diseases such as diabetes, where closed-loop bioelectronic medicine promises to provide real-time, autonomous and patient-specific therapies. In this article, we present an overview of the state-of-the-art for closed-loop neuromodulation systems in relation to diabetes and discuss future related opportunities for management of this chronic disease.