A Descriptive Study of Total Serum Homocysteine Status in Adult Henan Province, China
A Descriptive Study of Total Serum Homocysteine Status in Adult Henan Province, China
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中国河南省成人血清总同型半胱氨酸状况的描述性研究
DOI：
10.7754/clin.lab.2021.210531
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发表时间：
2022-02-08
影响因子：
0.7
通讯作者：
Ming, Liang
中科院分区：
文献类型：
--
作者：
Liu, Xia'nan;Wang, Xuebin;Ming, Liang
背景：高同型半胱氨酸血症（HHcy）是心血管疾病的独立危险因素。总血清同型半胱氨酸（tHcy）状态随种族和性别而变化很大。本研究通过调查不同年龄组和性别人群的tHcy浓度，计算不同年龄组和性别人群的HHcy患病率，对河南北方19岁以上10,258名（男7,248人，女3,010人）的tHcy状况进行了研究。用酶法测定tHcy水平。结果：总人群tHcy中位数为13.56（11.50，16.50）μ mol/L，HHcy患病率为34.61%。男性tHcy水平远高于女性：14.51（12.58，17.71）μ mol/L vs. 11.23（9.75，12.97）μ mol/L，p < 0.001。男性高同型半胱氨酸患病率明显高于女性（44.33%vs.11.20%，p < 0.001，OR = 6.33，95% CI：5.59 ± 7.14）。结论：北方地区高同型半胱氨酸的患病率较高。需要执行。
Background: Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Total serum homocysteine (tHcy) status varies greatly with ethnicity and gender. Here, we studied the tHcy status by investigating concentration of tHcy and calculating prevalence of HHcy according to different age groups and genders.Methods: This is a cross-sectional study of 10,258 participants (7,248 males and 3,010 females) above 19 years old from Henan Province, northern China. tHcy levels were determined enzymatically. HHcy was defined as a tHcy level higher than 15 mu mol/L.Results: In the whole population, the median value of tHcy was 13.56 (11.50, 16.50) mu mol/L, and the HHcy prevalence was 34.61%. Males had much higher tHcy levels than females: 14.51 (12.58, 17.71) mu mol/L vs. 11.23 (9.75, 12.97) mu mol/L, p < 0.001. Also, males had much higher HHcy prevalence than females (44.33% vs. 11.20%, p < 0.001, OR = 6.33, 95% CI: 5.59 7.14). HHcy prevalence and tHcy levels increased greatly for both genders above 60 years old.Conclusions: Our results demonstrated that prevalence of HHcy is very high in northern China. Implementation of is needed.