Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects
Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects
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DOI：
10.1007/s00421-006-0271-0
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发表时间：
2006-11-01
影响因子：
3
通讯作者：
Saugy, Martial
中科院分区：
文献类型：
--
作者：
Baume, Norbert;Schumacher, Yorck Olaf;Saugy, Martial
合成代谢雄激素类固醇（AAS）是兴奋剂，主要用于改善力量和肌肉肥大。在一些运动中，运动员报告说，AAS的摄入与更好的恢复，更高的训练负荷能力，从而增加身体和精神表现有关。本研究的目的是评估多剂量AAS对不同生理参数的影响，这些参数可能间接关系到运动员在艰苦的耐力训练计划中的身体状态。在双盲设置中，三组（n = 9、8和8）在1个月内口服安慰剂、十一酸睾酮或19-去甲雄烯二酮12次。在治疗期间评价血清生物标志物（肌酸激酶、ASAT和尿素）、血清激素特征（睾酮、皮质醇和LH）和尿儿茶酚胺（去甲肾上腺素、肾上腺素和多巴胺）。在干预阶段前后，通过标准化跑步机测试评估跑步表现。所有生化指标均未显示AAS对机体应激水平有显著影响。次最大和最大水平运动试验的数据未显示三组之间的任何性能差异或其对治疗的反应。在本研究中，未发现多次口服AAS对耐力表现或生物血清恢复标志物的影响。
Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n = 9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1 month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found.