Effects of TNF-α and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
Effects of TNF-α and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
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DOI：
10.1016/j.thromres.2004.10.010
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发表时间：
2005-01-01
影响因子：
7.5
通讯作者：
Chen, CY
中科院分区：
文献类型：
--
作者：
Nan, BC;Lin, P;Chen, CY
本研究的目的是阐明肿瘤坏死因子-α（TNF-α）对人内皮细胞血栓调节蛋白（TM）和内皮蛋白C受体（EPCR）表达的影响，以及姜黄素（一种香料和着色食品化合物）作为潜在治疗剂的作用。TNF-α（2.0 ng/ml）处理人脐静脉内皮细胞（HUVECs）后3、6、12和24 h TM mRNA水平分别降低80%、97%、94%和97%（P
The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent. Human umbilical vein endothelial cells (HUVECs) treated with TNF-alpha, (2.0 ng/ml) showed reduced TM mRNA levels by 80%, 97%, 94%, and 97% at 3, 6, 12, and 24 h, respectively (P