Vascular grading of angiogenesis: prognostic significance in breast cancer.
Vascular grading of angiogenesis: prognostic significance in breast cancer.
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DOI：
10.1054/bjoc.1999.0924
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发表时间：
2000-01
影响因子：
8.8
通讯作者：
Rose C
中科院分区：
文献类型：
--
作者：
Hansen S;Grabau DA;Sørensen FB;Bak M;Vach W;Rose C
该研究旨在通过原发性乳腺肿瘤的血管分级评估血管生成的预后价值，并评估将血管分级添加到诺丁汉预后指数（NPI）中的预后影响。该研究包括836名患者。中位随访时间为11年4个月。用抗CD34抗体对微血管进行化学染色。根据大部分血管肿瘤区域中预期的微血管数量，通过主观评分将血管生成半定量地分为三组。观察者之间的血管分级中度重现（κ = 0.59）。血管分级与腋窝淋巴结受累、肿瘤大小、恶性程度、雌激素受体状态和组织学类型显著相关。在单变量分析中，血管分级显著预测所有患者（P <0.0001）、淋巴结阴性患者（P <0.0001）和淋巴结阳性患者（P <0.0001）的无复发生存期和总生存期。考克斯多因素回归分析显示，血管分级是所有患者独立的预后价值（P <0.0001）。与NPI相比，包括血管分级在内的预后指数对24%的患者有临床影响，这些患者的预后组发生了变化，并暗示了更好的预后传播。我们的结论是血管分级确定的血管生成对乳腺癌患者具有独立的临床预后价值。2000癌症研究运动
The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI). The investigation included 836 patients. The median follow-up time was 11 years and 4 months. The microvessels were immunohistochemically stained by antibodies against CD34. Angiogenesis was graded semiquantitatively by subjective scoring into three groups according to the expected number of microvessels in the most vascular tumour area. The vascular grading between observers was moderately reproduced (κ = 0.59). Vascular grade was significantly associated with axillary node involvement, tumour size, malignancy grade, oestrogen receptor status and histological type. In univariate analyses vascular grade significantly predicted recurrence free survival and overall survival for all patients (P< 0.0001), node-negative patients (P< 0.0001) and node-positive patients (P< 0.0001). Cox multivariate regression analysis showed that vascular grading contributed with independent prognostic value in all patients (P< 0.0001). A prognostic index including the vascular grade had clinical impact for 24% of the patients, who had a shift in prognostic group, as compared to NPI, and implied a better prognostic dissemination. We concluded that the angiogenesis determined by vascular grading has independent prognostic value of clinical relevance for patients with breast cancer. © 2000 Cancer Research Campaign