LACK OF PROTECTIVE IMMUNITY AGAINST REINFECTION WITH HEPATITIS-C VIRUS
LACK OF PROTECTIVE IMMUNITY AGAINST REINFECTION WITH HEPATITIS-C VIRUS
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DOI：
10.1126/science.1279801
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发表时间：
1992-10-02
期刊：
影响因子：
56.9
通讯作者：
PURCELL, RH
中科院分区：
文献类型：
--
作者：
FARCI, P;ALTER, HJ;PURCELL, RH
一些感染丙型肝炎病毒（HCV）的人会经历多次急性肝炎。目前尚不清楚这些事件是由于丙型肝炎病毒的再感染还是由于原始病毒感染的重新激活。研究人员对 5 只黑猩猩进行了病毒复制和宿主免疫标志物的研究，这些黑猩猩在 3 年内连续接种了已证实具有传染性的不同 HCV 毒株。恢复期黑猩猩每次再次感染相同或不同的丙型肝炎病毒株都会导致病毒血症再次出现，这是由于感染了随后的攻击病毒。有证据表明，HCV 感染不会引发针对同源或异源毒株再次感染的保护性免疫，这引起了人们对开发有效的 HCV 疫苗的担忧。
Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.