ELECTROENCEPHALOGRAPHIC CHANGES DURING WHOLE-BODY HYPERTHERMIA IN HUMANS
ELECTROENCEPHALOGRAPHIC CHANGES DURING WHOLE-BODY HYPERTHERMIA IN HUMANS
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DOI：
10.1016/0013-4694(80)90015-2
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
MACNAMARA, TE
中科院分区：
文献类型：
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作者：
DUBOIS, M;SATO, S;MACNAMARA, TE
作为国家癌症研究所方案的一部分，21名选定的患者接受全身热疗治疗转移性癌。体温升高至41.8 ℃。使用计算机驱动的外部加热系统来实现2h。患者在治疗期间服用镇静剂。为了确保手术的安全性，监测了一系列生理参数。对所有患者进行连续EEG记录。EEG分析包括视觉评估、压缩谱阵列和功率谱。EEG数据主要与体温、意识状态和药物管理进行比较。在治疗期间，患者的意识从非常轻微的镇静到轻度麻醉不等，并伴有一些罕见的谵妄发作。未观察到运动性癫痫发作。所有EEG记录均显示节律性和振幅（较慢和较低）发生重大变化，表明在高热期间皮质活动弥漫性减少。所有的变化都在冷却期间逆转了。光谱功率与温度呈显著负相关。在41 ℃以上的温度下，C，总EEG频谱的减少与临床反应性的减少无关。EEG减慢的程度随高热的程度和持续时间而变化，并且在冷却的几个小时内完全可逆，没有任何EEG或神经学后遗症的证据。在41.5 ℃以上的温度下，C、脑电图改变与代谢性或中毒性脑病相符。
As part of a protocol of the National Cancer Institute, 21 selected patients were submitted to total body hyperthermia for treatment of metastatic carcinoma. Elevation of body temperature up to 41.8.degree. C for 2 h was achieved using a computer driven external heating system. Patients were sedated during treatment. To ensure the safety of the procedure, a battery of physiological parameters was monitored. Continuous EEG recordings were carried out in all patients. Analysis of the EEG included visual assessment, compressed spectral array and power spectrum. EEG data were compared mainly to body temperature, state of consciousness and drug administration. Consciousness during the treament varied from very light sedation to light anesthesia, with some rare delirious episodes. No motor seizures were observed. All EEG recordings demonstrated major changes in both rhythmicity and amplitude (slower and lower) indicating a diffuse decrease of cortical activity during the hyperthermia period. All changes reversed themselves during the cooling period. Spectral power showed a statistically significant inverse relationship with temperature. At temperatures above 41.degree. C, decrease in total EEG spectrum was not related to decrease in clinical reactivity. The degree of EEG slowing varied with the extent and duration of the hyperthermia, and was totally reversible within a few hours of cooling, without evidence of any EEG or neurological sequelae. At temperatures above 41.5.degree. C, EEG changes compatible with metabolic or toxic encephalopathy were observed.