Stress-relaxation response of human menisci under confined compression conditions
Stress-relaxation response of human menisci under confined compression conditions
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DOI：
10.1016/j.jmbbm.2013.05.027
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发表时间：
2013-10-01
影响因子：
3.9
通讯作者：
Duerselen, Lutz
中科院分区：
文献类型：
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作者：
Seitz, Andreas Martin;Galbusera, Fabio;Duerselen, Lutz
本研究的目的是确定人类半月板组织在受限压缩条件下应力松弛时的粘弹性特性。在三个压缩水平（epsilon=0.1; 0.15; 0.2）的受限压缩条件下，对25个供体膝关节（n（总）=150）的外侧和内侧纵向半月板塞进行应力松弛试验。采用指数一维扩散方程建立数学模型，对其粘弹性进行预测。随后，使用与体外试验相同的几何形状、特性和测试条件创建有限元模型。两种本构不同的基础数学公式应用于有限元模型，以揭示他们对松弛响应的预测可能存在的差异。第一个有限元模型模拟了解析模型（FE1），第二个有限元模型使用了不同的双相非线性方法（FE2）。回归分析表明，实验数据与扩散方程和两种有限元模型的预测结果具有较好的决定系数（R-2>0.73）。用扩散方程（H-A=64.0 kPa）预测的平均骨料模量低于两种有限元分析（H-A,H-FE1=91.9 kPa; H-A,H-FE2=81.5 kPa）得到的平均骨料模量。第二种方法的平均水力渗透率(k(FE2)=1.5 × 10（-15) m(4)/N s）具有统计学意义(p
The objective of this study was to determine the viscoelastic properties of human meniscal tissue during stress-relaxation under confined compression conditions. Lateral and medial longitudinal meniscus plugs of 25 donor knees (n(total)=150) were exposed to stress-relaxation tests under confined compression conditions at three compression levels (epsilon=0.1; 0.15; 0.2). Mathematical modelling using an exponential 1D-diffusion equation was used to predict the viscoelastic properties. Subsequently, finite element (FE) models were created using identical geometry, properties and test conditions as used for the in-vitro tests. Two constitutively different underlying mathematical formulations were applied to the FE models to reveal possible differences in their predictions for the relaxation response. While the first FE model mimicked the analytical model (FE1), the second FE model used a different biphasic, non-linear approach (FE2). Regression analyses showed promising coefficients of determination (R-2>0.73) between the experimental data and the predictions obtained from the diffusion equation and the two FE models. Mean aggregate modulus, predicted with the diffusion equation (H-A=64.0 kPa) was lower than those obtained with the two FE analyses (H-A,H-FE1=91.9 kPa; H-A,H-FE2=81.5 kPa). Mean hydraulic permeability (k(FE2)=1.5 x 10(-15) m(4)/N s) of the second FE2 approach was statistically lower (p