Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women.
Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women.
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DOI：
10.1093/jnci/djh042
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发表时间：
2004-03
期刊：
影响因子：
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通讯作者：
K. Woodson;A. Flood;L. Green;J. Tangrea;Jeffrey A Hanson;B. Cash;A. Schatzkin;P. Schoenfeld
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文献类型：
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作者：
K. Woodson;A. Flood;L. Green;J. Tangrea;Jeffrey A Hanson;B. Cash;A. Schatzkin;P. Schoenfeld
胰岛素样生长因子-II（IGF-II）的印记缺失（LOI）可能是一种遗传性表观遗传性状，在人群中具有多态性，其存在可能使个体易患结直肠癌。我们评估了参与结肠镜筛查研究的女性中正常结肠粘膜样本中IGF-II的LOI与腺瘤之间的相关性。在40例受试者中，11例（27.5%）在其正常结肠粘膜组织中存在IGF-II的LOI。校正体重指数和结直肠癌家族史后，LOI状态与腺瘤形成风险增加5倍相关（比值比= 5.2，95%置信区间= 1.0至26.7）。平均而言，IGF-II的表达是三倍以上的妇女与胰岛素样生长因子-II的LOI比正常的印迹状态的妇女。我们的研究结果支持IGF-II的LOI在人群中是一种表观遗传性状多态性的假设，并表明IGF-II的LOI可能在结直肠癌中发挥作用。这些发现是有趣的，需要在更大的研究中得到证实。
Loss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer. We evaluated the association between LOI of IGF-II in normal colonic mucosal samples and adenomas in women participating in a colonoscopy screening study. Among 40 participants, 11 (27.5%) had LOI of IGF-II in their normal colonic mucosal tissue. After adjusting for body mass index and family history of colorectal cancer, LOI status was associated with a fivefold increased risk of adenoma formation (odds ratio = 5.2, 95% confidence interval = 1.0 to 26.7). On average, IGF-II expression was more than threefold higher among women with LOI of IGF-II than among women with normal imprinting status. Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. These findings are intriguing and need to be confirmed in larger studies.