Degradation, characterization, ferrous ion chelating ability and repair effect of sulfated polysaccharides of six kinds of seaweed polysaccharides
Degradation, characterization, ferrous ion chelating ability and repair effect of sulfated polysaccharides of six kinds of seaweed polysaccharides
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六种海藻多糖硫酸化多糖的降解、表征、亚铁离子螯合能力及修复效果
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发表时间：
2018
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通讯作者：
Jian-Ming Ouyang
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作者：
Xin-Yuan Sun;Da Guo;Jian-Min Wang;Jian-Ming Ouyang
从海带、条斑紫菜、龙须菜、羊栖菜、麒麟菜和裙带菜中提取6种海藻多糖，对其进行降解和表征。这些多糖的硫酸基团（-OSO 3 H）含量分别为21.7%，17.9%，13.3%，8.2%，7.0%和5.5%。研究了这些多糖对亚铁离子的螯合能力和对损伤的人近端肾小管上皮细胞（HK-2）的修复作用。这些多糖具有较强的亚铁离子螯合能力，具有较高的抗氧化活性。每种多糖对琥珀酸诱导的HK-2细胞损伤均有修复作用。多糖的抗氧化活性和修复能力与其-OSO 3 H含量呈正相关。这些结果表明，这些多糖，特别是那些高含量的-OSO 3 H，可能是潜在的药物，用于预防和治疗草酸钙结石。
Six kinds of seaweed polysaccharides (SPSs) extracted from Laminaria japonica, Porphyra yezoensis, Gracilaria lemaneiformis, Sargassum fusiforme, Eucheuma gelatinae and Undaria pinnatifida were degraded and characterized. The sulfate group (-OSO3H) content of these polysaccharides were 21.7, 17.9, 13.3, 8.2, 7.0, and 5.5%, respectively. The ferrous ion chelating ability and repair effect on injured human kidney proximal tubular epithelial cells (HK-2) of these polysaccharides were studied. These polysaccharides had stronger ferrous ion chelating ability, suggesting that it possessed high antioxidant activity. Each polysaccharide had a repair effect on oxalate-induced damaged HK-2 cells. The antioxidant activity and repair ability of polysaccharide was positively correlated with its -OSO3H content. These results indicated that these polysaccharides, especially those with high -OSO3H content, may be potential drugs for the prevention and treatment of calcium oxalate stones.