Associations of CYP1 polymorphisms with risk of prostate cancer: an updated meta-analysis
Associations of CYP1 polymorphisms with risk of prostate cancer: an updated meta-analysis
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CYP1 多态性与前列腺癌风险的关联：更新的荟萃分析
DOI：
10.1042/bsr20181876
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发表时间：
2019-03-29
影响因子：
4
通讯作者：
Yang，Weimin
中科院分区：
文献类型：
--
作者：
Zhu，Wei;Liu，Hailang;Yang，Weimin
背景以往关于CYP 1A 1和CYP 1B 1基因多态性与前列腺癌（PCa）易感性关系的研究结果不一致。本研究的目的是进行荟萃分析，以更好地估计这种关联。方法.在PubMed、Embase、科克伦图书馆和中国知网（CNKI）数据库中对截至2018年8月15日发表的相关文章进行了系统检索。使用固定效应或随机效应模型获得合并优势比（OR）和95%置信区间。结果在整个人群中，发现CYP 1A 1 rs 1048943多态性与PCa之间存在显著关联（B与A的OR = 1.20，95%CI = 1.04-1.39，P=0.014; AB与AA的OR = 1.24，95%CI = 1.02-1.51，P=0.029; BB + AB vs. AA：OR = 1.25，95% CI = 1.04-1.50，P=0.018）和亚洲人群（B与A比较：OR = 1.32，95%CI = 1.11-1.56，P=0.001; BB与AA比较：OR = 1.81，95%CI = 1.20-2.72，P=0.005; AB与AA比较：OR = 1.30，95%CI = 1.03-1.64，P=0.029; BB + AB vs. AA：OR = 1.38，95% CI = 1.11-1.73，P=0.004; BB vs. AA + AB：OR = 1.58，95% CI = 1.08-2.01，P=0.019），但在白人人群中未发生。此外，我们发现rs 4646903多态性与亚洲人群（AB vs. AA：OR = 1.43，95%CI = 1.13-1.80，P=0.003）和白人人群（BB vs. AA：OR = 2.12，95%CI = 1.29-3.49，P=0.003）中PCa风险的显著增加相关。结论这项荟萃分析显示，CYP 1A 1基因的rs 1048943和rs 4646903多态性与PCa风险之间存在明确的相关性，但CYP 1B 1 rs 10012、rs 162549、rs 1800440和rs 2551188多态性与PCa风险之间无相关性。
Background. The results of previous studies on the association between polymorphisms of CYP1A1 and CYP1B1 and prostate cancer (PCa) susceptibility are inconsistent. The aim of the present study was to conduct a meta-analysis in order to better estimate this association. Methods. A systematic search was carried out on PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases for relevant articles published up to 15 August 2018. Pooled odds ratios (ORs) and 95% confidence intervals were obtained using fixed-effect or random-effect models. Results. A significant association was found between the CYP1A1 rs1048943 polymorphism and PCa in the overall population (B [the minor allele] vs. A [the major allele]: OR = 1.20, 95% confidence interval (CI) = 1.04–1.39, P=0.014; AB vs. AA: OR = 1.24, 95% CI = 1.02–1.51, P=0.029; BB + AB vs. AA: OR = 1.25, 95% CI = 1.04–1.50, P=0.018) and Asian population (B vs. A: OR = 1.32, 95% CI = 1.11–1.56, P=0.001; BB vs. AA: OR = 1.81, 95% CI = 1.20–2.72, P=0.005; AB vs. AA: OR = 1.30, 95% CI = 1.03–1.64, P=0.029; BB + AB vs. AA: OR = 1.38, 95% CI = 1.11–1.73, P=0.004; BB vs. AA + AB: OR = 1.58, 95% CI = 1.08–2.01, P=0.019), but not in the Caucasian population. Moreover, we found that the rs4646903 polymorphism was associated with a significant increase in the risk of PCa in the Asian population (AB vs. AA: OR = 1.43, 95% CI = 1.13–1.80, P=0.003) and Caucasian population (BB vs. AA: OR = 2.12, 95% CI = 1.29–3.49, P=0.003). Conclusion. This meta-analysis revealed a clear association between rs1048943 and rs4646903 polymorphisms of the CYP1A1 gene but not between CYP1B1 rs10012, rs162549, rs1800440, and rs2551188 polymorphisms and the risk of PCa.