Human proopiomelanocortin-(79-96), a proposed cortical androgen-stimulating hormone, does not affect steroidogenesis in cultured human adult adrenal cells.
Human proopiomelanocortin-(79-96), a proposed cortical androgen-stimulating hormone, does not affect steroidogenesis in cultured human adult adrenal cells.
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人阿片黑皮质素原 (79-96) 是一种拟议的皮质雄激素刺激激素，不会影响培养的成人肾上腺细胞中的类固醇生成。
DOI：
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发表时间：
1991
影响因子：
5.8
通讯作者：
J. Saez
中科院分区：
文献类型：
--
作者：
A. Penhoat;P. Sanchez;C. Jaillard;D. Langlois;M. Bégeot;J. Saez
皮质促雄激素（CASH）的存在，与ACTH不同，调节人肾上腺雄激素的分泌早已被假定。最近，据报道，一种18个氨基酸的肽，对应于阿黑皮素原[POMC-（79-96）]的连接肽的第一部分，能够刺激培养的成人肾上腺皮质细胞分泌脱氢表雄酮，但对皮质醇的产生没有影响。我们研究了ACTH（10（-11）和10（-9）M）、CASH-18（10（-8）M）或两者对成人肾上腺皮质细胞皮质醇和硫酸脱氢表雄酮的急性和长期作用。虽然ACTH增加类固醇分泌并增强对进一步ACTH刺激的类固醇生成反应，但CASH-18单独或与ACTH（10（-11）或10（-9）M）一起使用没有影响。此外，尽管[125 I] ACTH-（1-39）与相同的细胞制剂特异性结合，但我们无法证明[125 I] CASH-18与人肾上腺皮质细胞的任何特异性结合。
The existence of a cortical androgen-stimulating hormone (CASH), distinct from ACTH, regulating the secretion of human adrenal androgens has long been postulated. Recently, it has been reported that an 18-amino acid peptide, corresponding to the first part of the joining peptide of proopiomelanocortin [POMC-(79-96)], was able to stimulate the secretion of dehydroepiandrosterone from cultured human adult adrenocortical cells, but had no effect on cortisol production. We have studied the acute and long term effects of ACTH (10(-11) and 10(-9) M), CASH-18 (10(-8) M), or both on cortisol and dehydroepiandrosterone sulfate by human adult adrenocortical cells. Although ACTH increased steroid secretion and enhanced the steroidogenic responsiveness to further ACTH stimulation, CASH-18 alone or together with ACTH (10(-11) or 10(-9) M) had no effect. In addition, we were unable to demonstrate any specific binding of [125I]CASH-18 to human adrenocortical cells, although [125I] ACTH-(1-39) binds specifically to the same cell preparation.
人阿片黑皮质素原-(79-96) 是一种拟议的雄激素刺激激素，不会影响培养的人胎儿肾上腺细胞中的类固醇生成。
DOI：
10.1210/jcem-72-1-19
发表时间：
1991
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Mellon,SH;Shively,JE;Miller,WL
通讯作者：
Miller,WL