FETAL HB PRODUCTION DURING ACUTE ERYTHROID EXPANSION .1. OBSERVATIONS IN PATIENTS WITH TRANSIENT ERYTHROBLASTOPENIA AND POST-PHLEBOTOMY
FETAL HB PRODUCTION DURING ACUTE ERYTHROID EXPANSION .1. OBSERVATIONS IN PATIENTS WITH TRANSIENT ERYTHROBLASTOPENIA AND POST-PHLEBOTOMY
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DOI：
10.1111/j.1365-2141.1980.tb08707.x
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发表时间：
1980-01-01
影响因子：
6.5
通讯作者：
STAMATOYANNOPOULOS, G
中科院分区：
文献类型：
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作者：
PAPAYANNOPOULOU, T;VICHINSKY, E;STAMATOYANNOPOULOS, G
为了研究急性红细胞扩增过程中胎儿Hb的产生，连续测量了10例红细胞再生障碍、缺铁性贫血或放血后恢复的受试者的含Hb F的红细胞（F细胞）和相关血液学参数。在急性骨髓扩增过程中始终观察到F细胞的产生增加，但个体之间的最大F细胞反应存在显著差异。这些差异不能单独用贫血程度的差异来解释，也不能与网织红细胞峰值水平相关。两名患者谁达到最高的F-细胞数量可能是运营商的异细胞遗传持久性血红蛋白F，这表明该基因可能发挥作用，在确定贫血患者的F-细胞生产的幅度。在急性骨髓扩增期间持续观察到F细胞产生增加的主要原因显然是早期红系前体细胞（爆发形成单位; BFUe）的过早终末分化。这一主张与体外观察结果雅阁，体外观察结果表明，Hb F在源自BFUe的红系克隆中表达。BFUe募集程度的差异可能是受到类似贫血刺激的个体之间Hb F反应差异的基础。
To study fetal Hb production during acute erythroid expansion, sequential measurements were done of Hb F-containing erythrocytes (F-cells) and of relevant hematological parameters in 10 subjects recovering from erythroid aplasia, Fe deficiency anemia or following phlebotomy. Increased production of F-cells was consistently observed during the acute marrow expansion, but there were significant differences in maximum F-cell response among individuals. These differences could not be explained by differences in degree of anemia alone, nor could they be correlated with the level of peak reticulocytosis. Two patients who reached the highest F-cell numbers were probably carriers of heterocellular hereditary persistence of Hb F, suggesting that this gene may play a role in determining the magnitude of F-cell production in anemic patients. The main reason for the consistently observed increase in F-cell production during acute marrow expansion is apparently the premature terminal differentiation of earlier erythroid precursors (burst forming units; BFUe). This proposition is in accord with observations in vitro which suggest that Hb F is expressed in erythroid clones derived from BFUe. Differences in degree of BFUe recruitment may underly the disparities in Hb F response among individuals subjected to similar anemic stimuli.