Barrett's esophagus: Prevalence and risk factors in patients with chronic GERD in Upper Egypt
Barrett's esophagus: Prevalence and risk factors in patients with chronic GERD in Upper Egypt
复制标题
DOI：
10.3748/wjg.15.3511
复制
发表时间：
2009-07-28
影响因子：
4.3
通讯作者：
El-Khayat, Hisham R.
中科院分区：
文献类型：
--
作者：
Fouad, Yasser M.;Makhlouf, Madiha M.;El-Khayat, Hisham R.
目的：了解上埃及埃尔明亚和阿苏特地区慢性胃食道反流病(GERD)患者Barrett‘s Ereagus(BE)的患病率及其可能的危险因素。对患者进行病史调查，包括GERD症状问卷、临床检查和上消化道内窥镜检查。提示柱状衬里食道(CLE)的内窥镜征象被定义为粘膜舌或鳞状突交界处向上移位。病理检查发现疑似CLE患者出现特化肠化生，即诊断为BE。结果：有慢性GERD症状的患者中BE的发生率为7.3%，平均年龄为48.3±8.2岁，显著高于无BE的GERD患者(37.4±13.6岁)。腺癌8例(0.8%)，其中6例为BE患者。BE患者和GERD患者在性别、吸烟、饮酒或GERD症状方面没有显著差异。PH监测显示BE患者仰卧位食管酸暴露时间明显延长。结论：GERD患者行胃镜检查的BE患病率为7.3%。BE似乎与年龄较大有关，在夜间胃食道反流的患者中更多。(C)2009年WJG Press和Baishiden。版权所有。
AIM: To determine the prevalence and possible risk factors of Barrett's esophagus (BE) in patients with chronic gastroesophageal reflux disease (GERD) in El Minya and Assuit, Upper Egypt.METHODS: One thousand consecutive patients with chronic GERD symptoms were included in the study over 2 years. They were subjected to history taking including a questionnaire for GERD symptoms, clinical examination and upper digestive tract endoscopy. Endoscopic signs suggestive of columnar-lined esophagus (CLE) were defined as mucosal tongues or an upward shift of the squamocolumnar junction. BE was diagnosed by pathological examination when specialized intestinal metaplasia was detected histologically in suspected CLE. pH was monitored in 40 patients.RESULTS: BE was present in 7.3% of patients with chronic GERD symptoms, with a mean age of 48.3 +/- 8.2 years, which was significantly higher than patients with GERD without BE (37.4 +/- 13.6 years). Adenocarcinoma was detected in eight cases (0.8%), six of them in BE patients. There was no significant difference between patients with BE and GERD regarding sex, smoking, alcohol consumption or symptoms of GERD. Patients with BE had significantly longer esophageal acid exposure time in the supine position, measured by pH monitoring.CONCLUSION: The prevalence of BE in patients with GERD who were referred for endoscopy was 7.3%. BE seems to be associated with older age and more in patients with nocturnal gastroesophageal reflux. (C) 2009 The WJG Press and Baishideng. All rights reserved.