Bicaudal-D and its role in cargo sorting by microtubule-based motors
Bicaudal-D and its role in cargo sorting by microtubule-based motors
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DOI：
10.1042/bst0371066
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发表时间：
2009-10-01
影响因子：
3.9
通讯作者：
Li, Xuan
中科院分区：
文献类型：
--
作者：
Dienstbier, Martin;Li, Xuan
许多细胞质货物通过动力蛋白或动力蛋白分子马达沿着微管运输。由于细胞的分选机制需要严格控制，相关的因素被用来将货物招募到马达或调节其活动。在目前的综述中，我们主要关注BicD （Bicaudal-D）蛋白，该蛋白最近被认为是负端定向运动细胞质动力蛋白运输几种重要货物的必要元件。BicD被认为是连接货物和动力蛋白的纽带，尽管最近的研究表明它也可能在货物运动的调节中起作用。在这里，我们总结了BicD在多种细胞成分的运输中所起作用的当前知识。我们对支撑这些功能的分子相互作用进行了编目，并强调了未来需要解决的重要问题。
Many cytoplasmic cargoes are transported along microtubules using dynein or kinesin molecular motors. As the sorting machinery of the cell needs to be tightly controlled, associated factors are employed to either recruit cargoes to motors or to regulate their activities. In the present review, we concentrate on the BicD (Bicaudal-D) protein, which has recently emerged as an essential element for transport of several important cargoes by the minus-end-directed motor cytoplasmic dynein. BicD was proposed to be a linker bridging cargo and dynein, although recent studies suggest that it may also have roles in the regulation of cargo motility. Here we summarize the current knowledge of the role that BicD plays in the transport of diverse cellular constituents. We catalogue the molecular interactions that underpin these functions and also highlight important questions to be addressed in the future.