Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
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DOI：
10.1016/s0140-6736(99)06102-4
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发表时间：
1999-09-25
期刊：
影响因子：
168.9
通讯作者：
Reiss, P
中科院分区：
文献类型：
--
作者：
Brinkman, K;Smeitink, JA;Reiss, P
高效抗逆转录病毒疗法（HAART）可诱发外周脂肪消耗和中枢性肥胖的特征性脂肪营养不良综合征。尽管在不使用蛋白酶抑制剂的方案中也观察到了该综合征，但普遍认为 HIV-1 蛋白酶抑制剂是致病因素。在这里，我们假设核苷类似物逆转录酶抑制剂的线粒体毒性在这种脂肪营养不良的发展中起着重要作用，类似于线粒体缺陷在多发性对称性脂肪增多症的发展中的作用。
Highly active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome of peripheral fat wasting and central adiposity. HIV-1 protease inhibitors are generally believed to be the causal agents, although the syndrome has also been observed with protease-inhibitor-sparing regimens. Here, we postulate that the mitochondrial toxicity of the nucleoside-analogue reverse-transcriptase inhibitors plays an essential part in the development of this lipodystrophy, similar to the role of mitochondrial defects in the development of multiple symmetrical lipomatosis.