SARS-CoV-2 (COVID-19) Vaccine Development and Production: An Ethical Way Forward
SARS-CoV-2 (COVID-19) Vaccine Development and Production: An Ethical Way Forward
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DOI：
10.1017/s096318012000047x
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发表时间：
2021-01-01
影响因子：
1.8
通讯作者：
Iserson, Kenneth, V
中科院分区：
文献类型：
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作者：
Iserson, Kenneth, V
全世界都在等待SARS-CoV-2病毒（即，新冠肺炎（COVID-19疾病）疫苗，以保持民众健康，完全重新开放经济，并恢复他们的社会和医疗保健系统“正常”。“疫苗的安全性和有效性需要细致的测试和监督;本文描述了尽管有宏伟的公开声明，但目前的疫苗开发，测试和生产方法可能被证明在道德上是可疑的，医学上是危险的，社会上是不稳定的。基本的道德关切是对人类试验对象以及最终对许多疫苗接受者的健康的潜在危险。经济和政治压力使这一问题进一步复杂化，这些压力要求政府减少对仓促的疫苗测试和生产的监督，民族主义的分配目标，以及未能规划产生全球群体免疫所需的广泛免疫接种。正如本文所断言的，公众必须更好地了解情况，以评估正在生产的新型疫苗的承诺，并容忍拖延和不确定性。
The world awaits a SARS-CoV-2 virus (i.e., COVID-19 disease) vaccine to keep the populace healthy, fully reopen their economies, and return their social and healthcare systems to "normal." Vaccine safety and efficacy requires meticulous testing and oversight; this paper describes how despite grandiose public statements, the current vaccine development, testing, and production methods may prove to be ethically dubious, medically dangerous, and socially volatile. The basic moral concern is the potential danger to the health of human test subjects and, eventually, many vaccine recipients. This is further complicated by economic and political pressures to reduce government oversight on rushed vaccine testing and production, nationalistic distribution goals, and failure to plan for the widespread immunization needed to produce global herd immunity. As this paper asserts, the public must be better informed to assess promises about the novel vaccines being produced and to tolerate delays and uncertainty.