Effect of aging on lipid composition and metabolism in the adipose tissues of the rat
Effect of aging on lipid composition and metabolism in the adipose tissues of the rat
复制标题
衰老对大鼠脂肪组织脂质组成及代谢的影响
DOI：
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发表时间：
1961
期刊：
影响因子：
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通讯作者：
H. Kundel
中科院分区：
文献类型：
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作者：
W. Benjamin;A. Gellhorn;M. Wagner;H. Kundel
研究了38 ~ 647日龄大鼠脂肪组织的脂质代谢和化学变化。衰老过程的特点是乙酸脂合成显著减少，戊糖磷酸途径代谢的葡萄糖比例减少，棕榈酸掺入混合脂质的速率降低。在对照条件下，幼龄和老年组织中附睾脂肪对棕榈酸氧化为CO2和释放游离脂肪酸的作用相同；然而，当培养基中不含葡萄糖或添加肾上腺素时，与年老的脂肪组织相比，年轻人的棕榈酸氧化和游离脂肪酸释放率明显更高。测定了不同年龄时不同脂肪组织部位醋酸盐掺入混合脂质的速率。在所有年龄段，附睾、肾周、肠系膜和肩胛间脂肪组织的脂质生物合成率始终高于皮下脂肪组织。脂质合成速率…
Lipid metabolism and chemistry was studied in adipose tissues of the rat from the age of 38 days to 647 days. Aging process was characterized by a marked decrease in lipid synthesis from acetate, a reduction in the proportion of glucose metabolized by the pentose phosphate pathway, and a lower rate of palmitate incorporation into the mixed lipids. Oxidation of palmitic acid to CO2 and release of free fatty acid by epididymal fat was the same in young and old tissues under control conditions; when, however, glucose was absent from the medium or when epinephrine was added, there was a significantly greater rate of palmitic acid oxidation and free fatty acid release by young compared to old adipose tissue. Rate of acetate incorporation into mixed lipids by multiple adipose tissue sites was determined at different ages. Consistently greater rates of lipid biosynthesis were found in the epididymal, perirenal, mesenteric and interscapular adipose tissues than in subcutaneous fat at all ages. Rate of lipid synth...