The Usefulness of an Alternative Diagnostic Method for Sarcopenia Using Thickness and Echo Intensity of Lower Leg Muscles in Older Males
The Usefulness of an Alternative Diagnostic Method for Sarcopenia Using Thickness and Echo Intensity of Lower Leg Muscles in Older Males
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DOI：
10.1016/j.jamda.2019.01.152
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发表时间：
2019-09-01
影响因子：
7.6
通讯作者：
Rakugi, Hiromi
中科院分区：
文献类型：
--
作者：
Isaka, Masaaki;Sugimoto, Ken;Rakugi, Hiromi
目的：骨质疏松症的诊断依据是骨骼肌质量和肌力/功能，但超声仍需探索更简单、更准确的肌量和肌力/功能测量方法。设计：横断面研究。地点和对象：60名65岁及以上男性参加本研究。测量：超声测量小腿肌肉厚度(MT)和回声强度(EI)，并进行身体功能检查。应用受试者操作特征曲线分析小腿肌肉的MT和EI值预测低附件骨骼肌质量指数(ASMI)和低握力，并观察到显著的临界值。结果：在调整了年龄、体重指数、小腿围、糖尿病和他汀类药物的使用后，以MT和EI作为预测低ASMI和低握力的最佳分界点，发现胫骨前肌(TA)的MT、TA和腓肠肌的EI以及TA和比目鱼肌的MT/EI指数与骨质疏松症有关。结论/相关性：超声对小腿肌肉的评估可能是一种简便的检测石棺减少症的方法。特别是，TA的MT和EI的测定应被认为是筛查石棺减少症的一种替代方法。(C)2019年提交人(S)。由爱思唯尔公司代表AMDA(急性后和长期护理医学学会)出版。这是CC BY-NC-ND License(http://creativecommons.org/licenses/by-nc-nd/4.0/).下的一篇开放获取文章
Objectives: Sarcopenia is diagnosed on the basis of skeletal muscle mass and muscle strength/function; however, simpler and more accurate measures for muscle mass and muscle strength/function should be explored using ultrasonography. This study aimed to investigate a new screening method using ultrasonography to diagnose sarcopenia of lower leg muscles in older males.Design: Cross-sectional study.Setting and subjects: A total of 60 males, aged 65 years or older, participated in this study.Measures: The muscle thickness (MT) and echo intensity (EI) of the lower leg muscles were measured using ultrasonography, and the physical functions were examined. The MT and EI values of the lower leg muscles for predicting low appendicular skeletal muscle mass index (ASMI) and low grip strength were analyzed using receiver operating characteristic curve analysis and significant cutoff values were observed. A binary logistic regression analysis was performed with an MT below the cutoff value or an EI above the cutoff value as the independent variable, and with sarcopenia according to the Asian Working Group for Sarcopenia criterion as the dependent variable.Results: Using the optimal cutoff points of MT and EI for predicting a low ASMI and low grip strength, the MT of the tibialis anterior (TA), the EI of the TA and gastrocnemius, and the MT/EI index of the TA and soleus were found to be associated with sarcopenia after adjusting for age, body mass index, calf circumference, presence of diabetes mellitus, and statin use in the binary logistic regression model. In addition, the combined MT and EI of the TA showed predictability with respect to sarcopenia.Conclusions/Relevance: Ultrasonographic assessment of lower leg muscles might be useful as a convenient approach for detecting sarcopenia. In particular, the determination of both MT and EI of the TA should be considered as an alternative method of screening for sarcopenia. (C) 2019 The Author(s). Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).