Impaired lymphocyte and suppressor cell function in minimal change nephropathy, membranous nephropathy and focal glomerulosclerosis.
Impaired lymphocyte and suppressor cell function in minimal change nephropathy, membranous nephropathy and focal glomerulosclerosis.
复制标题
微小病变肾病、膜性肾病和局灶性肾小球硬化症中淋巴细胞和抑制细胞功能受损。
作者：
D. Taube;Z. Brown;D. Williams
在因微小病变肾病（11例）、局灶性肾小球硬化症（15例）和膜性肾病（21例）所致肾病综合征患者中测定淋巴细胞对伴刀豆球蛋白A（Con A）的反应;这些研究中未使用自体血清。与正常对照组相比，各组患者的淋巴细胞转化显著降低（每组p <0.01），但各组患者之间无显著差异。因此，淋巴细胞向Con A转化受损似乎是肾病综合征的一个普遍特征，并不局限于微小病变肾病。同时检测了4例微小病变型肾病、9例局灶性肾小球硬化和12例膜性肾病患者的抑制细胞功能。在每个组中抑制细胞的功能下降，表明受损的淋巴细胞反应，刀豆蛋白A是不是由于抑制细胞活性增加。这些发现并不支持微小病变型肾病所特有的淋巴细胞功能异常是该疾病的致病因素而不是肾病综合征的其他原因的假设;所描述的异常似乎更有可能继发于肾病状态。
The response of lymphocytes to Concanavalin A (Con A) was measured in patients with the nephrotic syndrome due to minimal change nephropathy (11 patients), focal glomerulosclerosis (15 patients) and membranous nephropathy (21 patients); autologous serum was not used in these studies. There was a significant reduction in lymphocyte transformation in each group of patients compared to normal controls (p less than 0.01 for each group), but there was no significant difference between the individual groups of patients. Impaired lymphocyte transformation to Con A appears therefore to be a general feature of the nephrotic syndrome and is not exclusive to minimal change nephropathy. Measurements of suppressor cell function in 4 patients with minimal change nephropathy, 9 patients with focal glomerulosclerosis and 12 patients with membranous nephropathy were performed at the same time as the above studies. In each group suppressor cell function was decreased, indicating that the impaired lymphocyte response to Con A is not due to increased suppressor cell activity. These findings do not support the hypothesis that an abnormality of lymphocyte function peculiar to minimal change nephropathy is pathogenetic in that disease and not in other causes of the nephrotic syndrome; it seems more likely that the abnormalities described are secondary to the nephrotic state.