Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
复制标题
阿尔茨海默病患者蓝斑中的去甲肾上腺素转运蛋白位点减少。
DOI：
10.1016/0006-8993(93)91201-3
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发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Zaffar,H
中科院分区：
文献类型：
--
作者：
Tejani-Butt,SM;Yang,J;Zaffar,H
本研究确定了[3H]尼索西汀与去甲肾上腺素转运体位点的结合是否会在阿尔茨海默病的整个蓝斑中均匀改变。[3H]尼索西汀结合在蓝斑座中部和尾侧区显著降低（P< 0.01），而在吻侧区无显著降低。[3H]尼索西汀与去甲肾上腺素转运蛋白位点结合的缺失可能归因于阿尔茨海默病中位于蓝斑中去甲肾上腺素能神经元末端的去甲肾上腺素转运蛋白位点的缺失。
The present study determined whether [3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly througout the locus coeruleus in Alzheimer's disease. A significant decrease (P< 0.01) in [3H]nisoxetine binding was seen in the mid and caudal regions but not in the rostral region of the locus coeruleus. The loss of [3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease.