Streptococcus suis infection:: a series of 41 cases from Chiang Mai University Hospital
Streptococcus suis infection:: a series of 41 cases from Chiang Mai University Hospital
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DOI：
10.1016/j.jinf.2005.02.012
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发表时间：
2006-06-01
影响因子：
28.2
通讯作者：
Supparatpinyo, Khuanchai
中科院分区：
文献类型：
--
作者：
Wangkaew, Suparaporn;Chaiwarith, Romanee;Supparatpinyo, Khuanchai
目的：本研究的目的是（1）评估泰国北部成年患者猪链球菌感染的临床表现、治疗和结果，（2）评估抗菌药物敏感性模式，以及（3）确定高死亡率的预测因素。方法：2000年5月至2002年12月在清迈大学医院进行回顾性研究。通过琼脂纸片扩散法和最小化法进行抗菌药敏试验。通过 E 测试测定抑菌浓度 (MIC)。结果：鉴定出 41 名猪链球菌感染患者（32 名男性和 9 名女性，平均年龄 51 岁）。 3名患者有猪或猪肉接触史，1名患者有生牛肉食用史。临床表现包括感染性心内膜炎、脑膜炎、败血症、椎间盘炎和眼内炎，分别有 16 例、13 例、10 例、1 例和 1 例。总死亡率为19.5%。单变量分析显示，低血清白蛋白、高血清总胆红素、低血小板和发病快与高死亡率显着相关。所有分离株均对青霉素敏感（平均MIC90=0.027μg/ml）。结论：猪链球菌感染在泰国北部并不罕见。高度怀疑和早期发现很重要，可以导致成功的治疗。 (C) 2006 年英国感染学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: The objectives of this study were (1) to assess the clinical manifestations, treatment, and outcome of Streptococcus suis infection in adult patients in northern Thailand, (2) to evaluate the anti-microbial sensitivity pattern and (3) to determine the predicting factors of high mortality rate.Methods: A retrospective study was conducted at Chiang Mai University Hospital from May 2000 to December 2002. Anti-microbial susceptibility test was performed by agar disk diffusion and the minimal inhibitory concentration (MIC) by E-test.Results: Forty-one patients (32 men and nine women, mean age 51 years) with S. suis infection were identified. Three patients had a history of exposure to pig or pork and one patient had a history of raw beef consumption. Clinical manifestations included infective endocarditis, meningitis, sepsis, spondylodiscitis, and endophthalmitis in 16, 13, 10, 1, and 1 patients, respectively. The overall mortality rate was 19.5%. On univariate analysis, low serum albumin, high serum total bilirubin, low platelet, and rapid onset of illness were significantly correlated with high mortality rate. All isolates were sensitive to penicillin (mean MIC90=0.027 mu g/ml).Conclusions: S. suis infection is not uncommon in northern Thailand. High suspicion and early detection are important and could Lead to the successful treatment. (C) 2006 The British Infection Society. Published by Elsevier Ltd. All rights reserved.