Extended treatment for cigarette smoking cessation: a randomized control trial.
Extended treatment for cigarette smoking cessation: a randomized control trial.
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戒烟的延长治疗：一项随机对照试验。
DOI：
10.1111/add.13806
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
David,SeanP
中科院分区：
文献类型：
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作者：
Laude,JenniferR;Bailey,SteffaniR;Crew,Erin;Varady,Ann;Lembke,Anna;McFall,Danielle;Jeon,Anna;Killen,Diana;Killen,JoelD;David,SeanP
目的检验长期戒烟患者延长认知行为疗法(CBT)的潜在益处。设计两组平行随机对照试验。在26周的开放标签治疗后，患者被随机分为非延长CBT(n=1111)或延长CBT(n=1112)。在美国设立社区诊所。参与者总共219名吸烟者(平均年龄：43岁；平均香烟/天：18)。干预所有参与者接受了10周的联合CBT+安非他酮缓释剂(安非他酮SR)+尼古丁贴片，并继续接受CBT治疗，如果戒烟，继续服用安非他酮+尼古丁替代疗法(NRT)，如果渴望或抑郁评分增加，则继续服用安非他酮+尼古丁替代疗法，或者如果10周时仍吸烟，则继续服用安非他酮+尼古丁替代疗法。一半的参与者在26周随机接受CBT(E-CBT)至48周，另一半接受非延长CBT(没有额外的CBT疗程)。主要结果是在52周和104周的随访中共同确认的过期的7天点患病率(PP)。分析基于意向治疗。在52周的随访中，未延长CBT组(40%)和E-CBT组(39%)的PP戒断率相似[优势比(OR)=0.99；95%可信区间(CI)=0.55，1.78]。在104周的随访中，未延长CBT组(39%)和E-CBT组(33%)也观察到了类似的情况(OR=0.79；95%CI=0.44，1.40)。结论将认知行为疗法延长26至48周似乎没有改善长期戒烟的效果。
AimTo test the potential benefit of extending cognitive–behavioral therapy (CBT) relative to not extending CBT on long‐term abstinence from smoking.DesignTwo‐group parallel randomized controlled trial. Patients were randomized to receive non‐extended CBT (n= 111) or extended CBT (n= 112) following a 26‐week open‐label treatment.SettingCommunity clinic in the United States.ParticipantsA total of 219 smokers (mean age: 43 years; mean cigarettes/day: 18).InterventionAll participants received 10 weeks of combined CBT + bupropion sustained release (bupropion SR) + nicotine patch and were continued on CBT and either no medications if abstinent, continued bupropion + nicotine replacement therapy (NRT) if increased craving or depression scores, or varenicline if still smoking at 10 weeks. Half the participants were randomized at 26 weeks to extended CBT (E‐CBT) to week 48 and half to non‐extended CBT (no additional CBT sessions).MeasurementsThe primary outcome was expired CO‐confirmed, 7‐day point‐prevalence (PP) at 52‐ and 104‐week follow‐up. Analyses were based on intention‐to‐treat.FindingsPP abstinence rates at the 52‐week follow‐up were comparable across non‐extended CBT (40%) and E‐CBT (39%) groups [odds ratio (OR) = 0.99; 95% confidence interval (CI) = 0.55, 1.78]. A similar pattern was observed across non‐extended CBT (39%) and E‐CBT (33%) groups at the 104‐week follow‐up (OR = 0.79; 95% CI= 0.44, 1.40).ConclusionProlonging cognitive–behavioral therapy from 26 to 48 weeks does not appear to improve long‐term abstinence from smoking.