The impact of HIV-related neuropsychological dysfunction on driving behavior
The impact of HIV-related neuropsychological dysfunction on driving behavior
复制标题
DOI：
10.1017/s1355617799577011
复制
发表时间：
1999-11-01
影响因子：
2.6
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Marcotte, TD;Heaton, RK;Grant, I
HIV感染通常会导致神经心理（NP）损伤。为了评估hiv相关的NP缺陷可能对汽车驾驶的影响，我们使用NP电池和两个基于pc的驾驶模拟评估了68名hiv血清阳性驾驶员。32名受试者被归类为NP受损；大多数（72%）仅显示出轻度损伤，没有人符合艾滋病毒相关痴呆的标准。在控制了免疫抑制程度和疾病分期后，np受损的参与者在先前验证的驾驶模拟中失败的比例远高于认知完好的参与者[OR = 5.3, 95% CI(1.7, 17.0), p = 0.006]。同样，在模拟城市驾驶中，NP受损的参与者更有可能失败，这取决于事故的数量[OR = 6.1, 95% CI (1.5, 24.6), p = 0.01]。模拟器的性能是通过在许多NP域中的功能来预测的，其中NP测试占模拟方差的13-30%。尽管将这些发现推断为道路驾驶障碍还为时过早，但他们确实认为应该更多地关注即使是轻微的hiv相关NP缺陷也可能对驾驶技能产生的影响。
HIV infection often results in neuropsychological (NP) impairment. In order to assess the impact that HIV-related NP deficits may have on automobile driving, we evaluated 68 HIV-seropositive drivers using an NP battery and two PC-based driving simulations. Thirty-two participants were classified as NP impaired; most (72%) evidenced only mild impairment, and none met criteria for HIV-associated dementia. After controlling for degree of immunosuppression and disease stage, NP-impaired participants failed a previously validated driving simulation at a much higher rate than cognitively intact participants [OR = 5.3, 95% CI(1.7, 17.0), p =.006]. Similarly, on a simulation of city driving, NP impaired participants were more likely to fail based upon the number of accidents [OR = 6.1, 95% CI (1.5, 24.6), p =.01]. Simulator performance was predicted by functioning in a number of NP domains, with NP tests accounting for 13-30% of the variance on the simulations. Although it would be premature to extrapolate these findings to impairment in on-the-road driving, they do argue for greater attention to the impact that even mild HIV-related NP deficits may have on driving skills.