Concentrating solutes and nanoparticles within individual aqueous microdroplets
Concentrating solutes and nanoparticles within individual aqueous microdroplets
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DOI：
10.1021/ac035196a
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发表时间：
2004-03-01
影响因子：
7.4
通讯作者：
Chiu, DT
中科院分区：
文献类型：
--
作者：
He, MY;Sun, CH;Chiu, DT
本文描述了一种方法来浓缩溶质和胶体实体，从小离子和分子到蛋白质和纳米颗粒，在油中的单个含水微滴内。其机理在于溶质被截留在含水微滴中，而来自微滴的水分子缓慢溶解到有机相中。由于浓度变化率的尺度为液滴表面积与体积比的五次方，因此这种现象在微米尺度上最为突出。Ibis论文提出了测量，定量的溶质截留的程度内的微滴，并进一步描述了液滴收缩的动力学和影响收缩率的因素。此外，本文解释了为什么这种浓度效应不发生某些有机微滴在水溶液中。
This paper describes a method to concentrate solutes and colloidal entities, from small ions and molecules to proteins and nanoparticles, within individual aqueous microdroplets in oil. The mechanism lies in the entrapment of the solutes within an aqueous microdroplet, while the water molecules from the droplet slowly dissolve into the organic phase. Because the rate of change in concentration scales as the fifth power of die surface-area-to-volume ratio of the droplet, this phenomenon is prominent mostly in the micrometer-length scale. Ibis paper presents measurements that quantify the degree of solute entrapment within the microdroplet and further describes the dynamics of droplet shrinkage and the factors that influence the rate of shrinkage. In addition, this paper explains why this concentration effect does not occur for certain organic microdroplets in aqueous solutions.