The use of oral radiographic contrast agents in the management of hyperthyroidism.
The use of oral radiographic contrast agents in the management of hyperthyroidism.
复制标题
口服放射造影剂在甲状腺功能亢进治疗中的应用。
DOI：
10.1089/105072501750302868
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Sarne,DH
中科院分区：
文献类型：
--
作者：
Fontanilla,JC;Schneider,AB;Sarne,DH
口服碘化造影剂如碘泊酸和碘番酸是治疗甲状腺功能亢进症的重要组成部分。它们迅速、显着地降低血清三碘甲状腺原氨酸 (T3)通过抑制外周甲状腺素（T4）转化为T3和阻断甲状腺分泌来降低水平。大量碘负荷导致的潜在风险 限制了它们的广泛应用。此外，如果长期单独使用，它们是无效的。然而，这些药物可能特别适用于治疗甲状腺功能亢进患者 术前，新生儿Graves病，大量左旋甲状腺素摄入，以及其他常规抗甲状腺药物不成功或禁忌时。
Oral iodinated radiographic contrast agents such as ipodate and iopanoic acid form an important part of the armamentarium used to treat hyperthyroidism. They rapidly and dramatically reduce serum triiodothyronine (T3) levels by inhibiting conversion of thyroxine (T4) to T3in the periphery and by blocking secretion from the thyroid. Potential risks from the large iodine load resulting from their use limit their widespread applicability. In addition, they are ineffective when used alone on a long-term basis. However, these agents may be especially useful in treating thyrotoxic patients preoperatively, in neonatal Graves' disease, in massive levothyroxine ingestion, and when other conventional antithyroid drugs are unsuccessful or contraindicated.