Post-translational regulation could be determine functional differences between SET alpha and beta isoform - Response to Cristóbal et al.
Post-translational regulation could be determine functional differences between SET alpha and beta isoform - Response to Cristóbal et al.
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翻译后调节可以确定 SET α 和 β 异构体之间的功能差异 - 对 Cristóbal 等人的回应。
DOI：
10.1111/bjh.15934
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发表时间：
2019
影响因子：
6.5
通讯作者：
Friedman,DaphneR
中科院分区：
文献类型：
--
作者：
Weinberg,JBrice;Brander,DanielleM;Christensen,DaleJ;Friedman,DaphneR
2019年《慢性淋巴细胞白血病中SET α和SET β mRNA亚型》一文的作者回应了对该文章的评论。他们引用了SETA: SETB mRNA异构体比例与白血病临床侵袭性的相关性，其转录调节SET异构体表达，可以调节其水平并最终抑制PP2A活性并影响CLL患者的预后。还注意到需要对调查结果进行进一步调查。
The authors of the article" SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia" respond to comments on it in 2019. They cite their demonstration of the correlation of SETA: SETB mRNA isoform ratios with clinical aggressiveness of the leukaemia, which transcriptionally regulates SET isoform expression that can modulate its levels and eventually inhibit PP2A activity and influence CLL patient outcomes. Also noted is the need for further investigation on the findings.