The manganese health research program (MHRP): Status report and future research needs and directions
The manganese health research program (MHRP): Status report and future research needs and directions
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DOI：
10.1016/j.neuro.2005.10.005
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发表时间：
2006-09-01
期刊：
影响因子：
3.4
通讯作者：
Tremblay, A.
中科院分区：
文献类型：
--
作者：
Aschner, M.;Lukey, B.;Tremblay, A.
锰 (Mn) 研究健康计划 (MHRP) 研讨会是第 22 届国际神经毒理学会议上的一整天会议。锰是许多国防和国防相关私营部门应用中的关键金属，包括炼钢和制造、提高燃料效率和焊接，并且是便携式电源（电池）中至关重要的大型组件。目前，关于在这些和其他应用中使用锰对健康的潜在不利影响存在很多争论。由于国防部、其承包商和供应商大量使用锰，锰健康研究计划 (MHRP) 寻求利用联邦政府的资源，与锰研究人员以及涉及锰的行业合作，确定锰对健康的确切影响，并为公共和私营部门工人制定适当的保障措施。人类需要锰作为基本元素；然而，接触高浓度的这种金属有时会对健康产生不利影响，尤其是对中枢神经系统的影响。暴露场景因地理位置、城市与农村环境、生活方式、饮食和职业环境而有很大差异。此外，暴露可能是短暂的或长期的，可能是不同类型的锰化合物（具有不同物理和/或化学性质的锰盐或气溶胶），并且可能发生在不同的生命阶段（例如，子宫内、新生儿期、青春期、成年期或衰老期）。这些因素以及影响背景和疾病发生的不同遗传组成可能反映了个体对锰暴露的不同敏感性。解开这些复杂性需要采用多管齐下的研究方法来解决有关锰作为必需金属的作用及其对疾病过程和功能障碍的调节的多个问题。 1005 年 9 月 14 日星期三举行了一次关于锰 (Mn) 对健康影响的研讨会，讨论了对锰在健康和疾病中的作用的理解进展。该研讨会由锰健康研究计划（MHRP）主办。本摘要提供了 MHRP 的背景，确定了研讨会上讨论的演讲者和主题，并确定了研究需求和理解锰健康和疾病相关问题的预期进展。 (C)2005 Elsevier Inc. 保留所有权利。
The manganese (Mn) research health program (MHRP) symposium was a full day session at the 22nd International Neurotoxicology Conference.Mn is a critical metal in many defense and defense-related private sector applications including steel making and fabrication, improved fuel efficiency, and welding, and a vital and large component in portable power sources (batteries). At the current time, there is much debate concerning the potential adverse health effects of the use of manganese in these and other applications. Due to the significant use of manganese by the Department of Defense, its contractors and its suppliers, the Manganese Health Research Program (MHRP) seeks to use the resources of the federal government, in tandem with manganese researchers, as well as those industries that are involved with manganese, to determine the exact health effects of manganese, as well as to devise proper safeguard measures for both public and private sector workers.Humans require manganese as an essential element; however, exposure to high levels of this metal is sometimes associated with adverse health effects, most notably within the central nervous system. Exposure scenarios vary extensively in relation to geographical location, urban versus rural environment, lifestyles, diet, and occupational setting. Furthermore, exposure may be brief or chronic, it may be to different types of manganese compounds (aerosols or salts of manganese with different physical and/or chemical properties), and it may occur at different life-stages (e.g., in utero, neonatal life, puberty, adult life, or senescence). These factors along with diverse genetic composition that imposes both a background and disease occurrence likely reflect on differential sensitivity of individuals to manganese exposure. Unraveling these complexities requires a multipronged research approach to address multiple questions about the role of manganese as an essential metal as well as its modulation of disease processes and dysfunction.A symposium on the Health Effects of Manganese (Mn) was held on Wednesday, September 14, 1005, to discuss advances in the understanding on role of Mn both in health and disease. The symposium was sponsored by the Manganese Health Research Program (MHRP). This summary provides background on the MHRP, identifies the speakers and topics discussed at the symposium, and identifies research needs and anticipated progress in understanding Mn health- and disease-related issues. (C)2005 Elsevier Inc. All rights reserved.