Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
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DOI：
10.1083/jcb.200302070
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发表时间：
2003-05-12
影响因子：
7.8
通讯作者：
Tsukita, S
中科院分区：
文献类型：
--
作者：
Nitta, T;Hata, M;Tsukita, S
紧密连接在中枢神经系统中血管的相邻内皮细胞之间发育良好，在建立血脑屏障中发挥核心作用（131313）。Claudin-5是脑内皮细胞紧密连接的主要细胞粘附分子。为了检查其在BBB中的可能参与，产生了claudin-5缺陷小鼠。在这些小鼠的大脑中，血管的发育和形态没有改变，没有出血或水肿。然而，示踪实验和磁共振成像显示，在这些小鼠中，131313对小分子（
Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (131313). Claudin-5 is a major cell adhesion molecule of tight junctions in brain endothelial cells. To examine its possible involvement in the BBB, claudin-5-deficient mice were generated. In the brains of these mice, the development and morphology of blood vessels were not altered, showing no bleeding or edema. However, tracer experiments and magnetic resonance imaging revealed that in these mice, the 131313 against small molecules (