The role of the thickness and the substrate on the in vitro bioactivity of silica-based glass coatings
The role of the thickness and the substrate on the in vitro bioactivity of silica-based glass coatings
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DOI：
10.1016/j.msec.2005.01.015
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发表时间：
2005-04
期刊：
影响因子：
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通讯作者：
J. Borrajo;P. González;S. Liste;J. Serra;S. Chiussi;B. Léon;M. Pérez-Amor
中科院分区：
文献类型：
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作者：
J. Borrajo;P. González;S. Liste;J. Serra;S. Chiussi;B. Léon;M. Pérez-Amor
本文介绍了用脉冲激光沉积法在硅和钛基体上生长生物活性玻璃涂层的体外性能。评价了当浸入模拟体液中时产生完整生物活性反应所需的涂层的临界厚度。薄涂层的反应性，从而导致生产磷酸钙和富硅层的基板上的影响，进行了讨论。此外，生物活性过程的时间演变的厚生物活性玻璃涂层沉积在生物形态碳化硅陶瓷。在涂层多孔材料的体外试验中，表面积与模拟体液体积的比率被揭示为关键参数。应仔细估计有效表面积，以避免对生物活性过程产生不利影响。
The in vitro behaviour of bioactive glass coatings grown by Pulsed Laser Deposition on silicon and titanium substrates is presented. The critical thickness of the coatings needed to develop the complete bioactive reactions when immersed in Simulated Body Fluid was evaluated. The influence of the substrate on the reactivity of thin coatings, which lead to the production of calcium phosphate and silica-rich layers, is discussed. Furthermore, the temporal evolution of the bioactivity process was followed for thick bioactive glass coatings deposited on biomorphic silicon carbide ceramics. In the in vitro tests of coated porous materials, the surface area to volume of Simulated Body Fluid ratio was revealed as a key parameter. The effective surface area should be carefully estimated in order to avoid adverse effects on the bioactive process.