Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer
Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer
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DOI：
10.1016/j.ejso.2006.07.009
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发表时间：
2006-12-01
期刊：
影响因子：
3.8
通讯作者：
Ricci, R.
中科院分区：
文献类型：
--
作者：
D'Ugo, D.;Persiani, R.;Ricci, R.
目的：本研究的目的是评价新辅助化疗（NACT）对一系列局部进展期胃癌的影响及其对生存期的影响。方法：对30例连续完成3年随访的患者进行治疗前临床分期、腹腔镜分期和术后病理分期的比较。NACT诱导的肿瘤消退与3年生存率的统计学相关性包括肿瘤降期和病理反应分级。结果：30例患者中有13例肿瘤分期降低。3年随访结束后，总生存期为37.5个月，总生存率为56.7%；在ro切除术受益的病例中，这一数字高达70.8%（24/30例：ro切除术率80.0%）。结论：在本研究中，局部晚期胃癌在“D2”手术切除前接受NACT治疗的3年生存率优于单纯手术治疗的历史系列。根据一项为期3年的完整随访，获得t降级并随后受益于ro切除术的患者有更大的治愈机会。(c) 2006 Elsevier Ltd.版权所有。
Aims: Aim of this study is the evaluation of the effects induced by neoadjuvant chemotherapy (NACT) and its impact oil survival on a series of locally advanced gastric carcinomas.Methods: Downstaging was assessed comparing pre-treatment clinical and laparoscopic staging with post-operative pathologic staging on 30 consecutive patients who completed a 3-year follow-up. Tumor downstaging and the grade of pathologic response were included in a statistical correlation between tumor regression induced by NACT and 3-year survival.Results: In this series tumor downstaging was obtained in 13 out of 30 patients. After the completion of 3-year follow-up, overall Survival was > 37.5 months with an overall survival rate of 56.7%; this figure reached up to 70.8% in those cases who benefited from a RO-resection (24/30 patients: RO-resection rate 80.0%).Conclusions: In this study the 3-year survival for locally advanced gastric cancer treated by NACT prior to "D2" surgical resection, compares favourably with historical series treated by surgery alone. Patients who obtained T-downstaging and subsequently benefited from a RO-resection had a definitely better chance of cure, according to a complete 3-year follow-up. (c) 2006 Elsevier Ltd. Ail rights reserved.