Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
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DOI：
10.1093/ajcn/77.5.1140
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发表时间：
2003-05-01
影响因子：
7.1
通讯作者：
Cleland, LG
中科院分区：
文献类型：
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作者：
James, MJ;Ursin, VM;Cleland, LG
背景资料：对于许多希望获得膳食n-3脂肪酸提供的健康益处的人来说，每天摄入鱼或鱼油不是一种可持续的长期方法。为了增加可持续饮食选择的数量，需要一种能有效增加长链n-3脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）组织浓度的n-3脂肪酸陆地来源。目的：本研究的目的是探讨膳食十八碳四烯酸（SDA）以增加健康人类受试者中EPA和DHA的组织浓度，并比较SDA与n-3脂肪酸α-亚麻酸（ALA）和EPA的有效性。健康男性和绝经后女性受试者每天摄入胶囊化SDA、ALA或EPA，剂量为0.75 g，然后为1.5 g，持续3周（n = 15/组），采用双盲、平行组设计。膳食SDA增加EPA和二十二碳五烯酸的浓度，但不DHA的浓度在红细胞和血浆磷脂。测试的膳食脂肪酸在增加组织EPA的相对有效性为1：0.3：0.07 EPA：SDA：ALA.Conclusions：含有SDA的植物油可能是一种膳食来源的n-3脂肪酸，这将是更有效地增加组织EPA浓度比目前ALA含植物油。在食品制造中使用含SDA的油可以提供广泛的膳食替代品来提高组织EPA浓度。
Background: For many persons who wish to obtain the health benefits provided by dietary n-3 fatty acids, daily ingestion of fish or fish oil is not a sustainable long-term approach. To increase the number of sustainable dietary options, a land-based source of n-3 fatty acids that is effective in increasing tissue concentrations of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is required.Objective: The objective of the study was to examine the ability of dietary stearidonic acid (SDA) to increase tissue concentrations of EPA and DHA in healthy human subjects and to compare the effectiveness of SDA with that of the n-3 fatty acids alpha-linolenic acid (ALA) and EPA.Design: Encapsulated SDA, ALA, or EPA was ingested daily in doses of 0.75 g and then 1.5 g for periods of 3 wk each by healthy male and postmenopausal female subjects (n = 15/group) in a double-blind, parallel-group design.Results: Dietary SDA increased EPA and docosapentaenoic acid concentrations but not DHA concentrations in erythrocyte and in plasma phospholipids. The relative effectiveness of the tested dietary fatty acids in increasing tissue EPA was 1:0.3:0.07 for EPA:SDA:ALA.Conclusions: Vegetable oils containing SDA could be a dietary source of n-3 fatty acids that would be more effective in increasing tissue EPA concentrations than are current ALA-containing vegetable oils. The use of SDA-containing oils in food manufacture could provide a wide range of dietary alternatives for increasing tissue EPA concentrations.