SUBSEQUENTLY ENHANCED CPP TO MORPHINE FOLLOWING CHRONIC BUT NOT ACUTE FOOTSHOCK STRESS ASSOCIATED WITH CORTICOSTERONE MECHANISM IN RATS
SUBSEQUENTLY ENHANCED CPP TO MORPHINE FOLLOWING CHRONIC BUT NOT ACUTE FOOTSHOCK STRESS ASSOCIATED WITH CORTICOSTERONE MECHANISM IN RATS
复制标题
DOI：
10.1080/00207450600936619
复制
发表时间：
2007-01
影响因子：
2.2
通讯作者：
Yan Li;Gong-ying Li;Ling-jiang Li;CHONG-HONG Wang;Zedong Li;JIN-LI Zhang;Jing Zhang;Weihe Li
中科院分区：
文献类型：
--
作者：
Yan Li;Gong-ying Li;Ling-jiang Li;CHONG-HONG Wang;Zedong Li;JIN-LI Zhang;Jing Zhang;Weihe Li
本研究的目的是确定预先暴露于足电击应激和皮质酮（CORT）的大鼠吗啡诱导的位置偏爱。作者还研究了多巴胺机制在CORT诱导的位置偏爱中的作用。结果表明，慢性足电击或CORT暴露同样增强了吗啡的条件性位置偏爱，而急性足电击或CORT暴露则没有。高、中剂量（5、3 mg/kg）CORT可诱导大鼠产生条件性位置偏爱。大鼠腹腔注射CORT（5、3、1 mg/kg）后，NAc内多巴胺含量明显降低。显著增加。结果提示，CORT引起的NAc多巴胺水平升高可能是应激与吗啡之间的中介。
The purpose of this study was to determine the morphine-induced place preference in rats pre-exposed to footshock stress and corticosterone (CORT). The authors also studied the involvement of dopamine mechanisms in the CORT-induced place preference. The results showed that chronic footshock or CORT exposure but not acute footshock or CORT exposure similarly potentiated the conditioned place preference to morphine. The CORT-induced conditioned place preference were established only with high and middle dose (5, 3 mg/kg) CORT. The dopamine levels in NAc of rats injected with CORT (5, 3, 1 mg/kg, i.p.) increased significantly. The findings suggest that the increase of dopamine levels in NAc induced by CORT might be the medium between stress and morphine.