Interpretation and use of FRAX in clinical practice
Interpretation and use of FRAX in clinical practice
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DOI：
10.1007/s00198-011-1713-z
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发表时间：
2011-09-01
影响因子：
4
通讯作者：
McCloskey, E. V.
中科院分区：
文献类型：
--
作者：
Kanis, J. A.;Hans, D.;McCloskey, E. V.
WHO FRAXA（R）算法的引入促进了基于骨折概率的骨折风险评估。其在骨折风险预测中的使用有其优点，但也存在临床医生应该意识到的局限性，也是本次综述的重点。 引言 国际骨质疏松症基金会 (IOF) 和国际临床密度测量学会 (ISCD) 任命了一个联合工作组来开发资源文件，以便就如何改进 FRAX 提出建议，并更好地为使用 FRAX 的临床医生提供信息。工作组于 2010 年 11 月召开了为期 3 天的会议，讨论了构成本次审查重点的这些主题。方法本研究审查了 ISCD 和 IOF 的资源文件和联合立场声明。结果提供了 FRAX 目前使用的临床风险因素的详细信息，并提供了排除其他因素的原因。在无法获得特定国家 FRAX 模型的情况下，建议开发替代模型。 结论 临床医生对 FRAX 调节的愿望清单很大，但在许多情况下，这些愿望目前无法实现；然而，对其原因的解释和理解可能有助于将 FRAX 提供的信息转化为临床实践。
The introduction of the WHO FRAXA (R) algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this reviewIntroduction The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review.Methods This study reviews the resource documents and joint position statements of ISCD and IOF.Results Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available.Conclusions The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.