A roadmap for functional structural variants in the soybean genome.
A roadmap for functional structural variants in the soybean genome.
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DOI：
10.1534/g3.114.011551
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发表时间：
2014-05-22
期刊：
影响因子：
--
通讯作者：
Stupar RM
中科院分区：
文献类型：
--
作者：
Anderson JE;Kantar MB;Kono TY;Fu F;Stec AO;Song Q;Cregan PB;Specht JE;Diers BW;Cannon SB;McHale LK;Stupar RM
基因结构变异（SV）是近年来发现的一种重要的遗传机制。我们筛选了一组41个大豆（Glycine max）种质作为亲本在大豆巢式关联作图群体中的缺失和重复超过53，000个基因模型。阵列杂交和全基因组重测序方法被用作互补技术，以确定SV在1528个基因，或约2.8%，大豆基因模型。虽然SV发生在整个基因组，SV富集在家庭的生物防御反应基因。在加入，SV是近八倍，少频繁的基因模型，保留旁系同源物，因为最后一个全基因组重复事件，与基因没有保留旁系同源物。基因拷贝数的增加，类似于在Rhg 1抗性位点描述的，约占基因SV事件的四分之一。大豆SV发生的这一评估提出了一个可能负责快速进化和/或适应性性状的基因的目标列表。
Gene structural variation (SV) has recently emerged as a key genetic mechanism underlying several important phenotypic traits in crop species. We screened a panel of 41 soybean (Glycine max) accessions serving as parents in a soybean nested association mapping population for deletions and duplications in more than 53,000 gene models. Array hybridization and whole genome resequencing methods were used as complementary technologies to identify SV in 1528 genes, or approximately 2.8%, of the soybean gene models. Although SV occurs throughout the genome, SV enrichment was noted in families of biotic defense response genes. Among accessions, SV was nearly eightfold less frequent for gene models that have retained paralogs since the last whole genome duplication event, compared with genes that have not retained paralogs. Increases in gene copy number, similar to that described at the Rhg1 resistance locus, account for approximately one-fourth of the genic SV events. This assessment of soybean SV occurrence presents a target list of genes potentially responsible for rapidly evolving and/or adaptive traits.
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