Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population
Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population
复制标题
MHC区HLA-DPB105:01基因和BTNL2基因与中国汉族人群寻常型银屑病临床表型的相关性分析
DOI：
10.1002/jgm.2961
复制
发表时间：
2017-09-01
影响因子：
3.5
通讯作者：
Zhang, Xuejun
中科院分区：
文献类型：
--
作者：
Guo, Huimin;Huang, Yong;Zhang, Xuejun
背景
人类主要组织相容性复合体（MHC）具有高度多态性，并且已被确定与众多疾病相关。HLA - DPB1和BTNL2基因首次被发现与银屑病相关。本研究旨在探讨HLA - DPB1和BTNL2基因与寻常型银屑病（PV）临床表型的相关性。
方法
为了研究HLA - DPB1和BTNL2基因多态性是否与中国汉族人群中PV的临床表型相关，我们通过MHC靶向测序分层分析在病例 - 对照和仅病例受试者（9906例对照和8744例病例）中进行了分析。
结果
在病例和对照中，分析表明HLA - DPB1*05:01基因型与点滴状类型[p = 3.914×10⁻²，优势比（OR = 0.9335）]和北方地区（p = 1.182×10⁻³，OR = 0.9108）相关。在仅病例分析中，HLA - DPB1*05:01基因型与地理区域显著相关（p = 1.36×10⁻³，OR = 1.134）。在病例和对照中，分析表明BTNL2（rs41355746）基因型与男性（p = 2.563×10⁻²，OR = 0.8897）、早发（p = 9.399×10⁻³，OR = 0.8856）、点滴状（p = 2.469×10⁻²，OR = 0.8558）和家族史（p = 1.51×10⁻⁴，OR = 0.772）相关。在仅病例分析中，BTNL2（rs41355746）基因型与家族史（p = 1.768×10⁻³，OR = 0.757）和发病年龄（p = 3.818×10⁻²，OR = 1.195）显著相关。
结论
本研究结果表明，HLA - DPB1*05:01基因与PV的地理区域相关，BTNL2基因与PV的家族史和发病年龄显著相关。总之，HLA - DPB1*05:01和BTNL2基因可能是临床特征复杂性的原因。
BackgroundThe human major histocompatibility complex (MHC) is known to be highly polymorphic and has been identified to be associated with numerous diseases. The HLA-DPB1 and BTNL2 genes were associated with psoriasis for the first time. The present study aims to investigate the relevance of the HLA-DPB1 and BTNL2 genes with respect to clinical phenotypes of psoriasis vulgaris (PV).MethodsTo investigate whether the HLA-DPB1 and BTNL2 polymorphisms were associated with clinical phenotypes of PV in Chinese Han population, we conducted an analysis in case-controls and case-only subjects (9906 controls and 8744 cases) via MHC targeted sequencing stratified analysis.ResultsIn cases and controls, analysis showed that the genotype of HLA-DPB1*05:01 was associated with type of guttate [p=3.914x10(-2), odds ratio (OR=0.9335)] and northern region (p=1.182x10(-3), OR=0.9108). In the case-only analysis, the genotype of HLA-DPB1*05:01 was significantly correlated with geographical region (p=1.36x10(-3), OR=1.134). In cases and controls, analysis showed that the genotype of BTNL2 (rs 41355746) was associated with being male (p=2.563x10(-2), OR=0.8897), early-onset (p=9.399x10(-3), OR=0.8856), guttate (p=2.469x10(-2), OR=0.8558) and family history (p=1.51x10(-4), OR=0.772). In the case-only analysis, the genotype of BTNL2 (rs41355746) was significantly correlated with family history (p=1.768x10(-3), OR=0.757) and age of onset (p=3.818x10(-2), OR=1.195).ConclusionsThe results of the present study indicate that the HLA-DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA-DPB1*05:01 and BTNL2 genes might be responsible for the complicacy of clinical features.