The effect of low level acoustic stimulation on susceptibility to noise in blue- and brown-eyed young human subjects
The effect of low level acoustic stimulation on susceptibility to noise in blue- and brown-eyed young human subjects
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DOI：
10.1097/00003446-199602000-00008
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发表时间：
1996-02-01
期刊：
影响因子：
3.7
通讯作者：
Hellstrom, PA
中科院分区：
文献类型：
--
作者：
Barrenas, ML;Hellstrom, PA
目的：本研究的目的是探讨色素沉着对低水平声刺激（LLAS）引起的暂时性噪声引起的阈值偏移（TTS）降低的影响。色素依赖性LLAS对TTS的影响可以解释为黑素细胞参与LLAS。它不能解释耳蜗感觉神经结构的变化ONLY.DESIGN：青少年根据眼睛颜色分类（n = 6 + 6），并暴露于音乐在70分贝6小时，每天9天（LLAS）。TTS测量之前，期间和之后的LLAS period.Results：结果表明，LLAS减少TTS显着更多的蓝眼睛比棕色眼睛的科目。TTS的差异保持至少1周后停止LLAS.Conclusions：这表明，观察到的差异LLAS效果是由于黑素细胞的差异，在自由基防御。也有可能是其他耳蜗抗氧化酶系统，负责灭活有害的氧自由基，同时参与黑色素合成，如硫氧还蛋白还原酶/硫氧还蛋白电子转移系统被激活。
Objective: The aim of this study was to investigate the influence of pigmentation on the reduction in temporary noise-induced threshold shift (TTS) due to low level acoustic stimulation (LLAS). A pigmentation-dependent LLAS effect on TTS could be interpreted as a strial melanocyte involvement in LLAS. It could not be explained by cochlear sensorineural structure changes only.Design: Teenagers were classified according to eye color (n = 6 + 6) and exposed to music at 70 dBA 6 h per day for 9 days (LLAS). TTS was measured before, during, and after the LLAS period.Results: It was shown that LLAS reduced TTS significantly more in blue-eyed than in brown-eyed subjects. The difference in TTS remained for at least 1 wk after the cessation of LLAS.Conclusions: It is suggested that the observed difference in LLAS effect is due to strial melanocyte differences in free radical defense. It is also possible that other cochlear antioxidant enzyme systems, responsible for inactivation of harmful oxygen radicals and simultaneously involved in melanin synthesis such as the thioredoxin reductase/thioredoxin electron transfer system are activated.