Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells
Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells
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阿托伐他汀通过减少 Th1/Th17 细胞因子和上调 T 调节细胞来改善实验性自身免疫性神经炎
DOI：
10.1016/j.cellimm.2011.08.015
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发表时间：
2011-01-01
影响因子：
4.3
通讯作者：
Duan, Rui-Sheng
中科院分区：
文献类型：
--
作者：
Li, Xiao-Li;Dou, Ying-Chun;Duan, Rui-Sheng
他汀类药物具有抗炎和免疫调节作用。为探讨阿托伐他汀对格林-巴利综合征(GBS)动物模型实验性自身免疫性神经炎(EAN)的影响，用完全弗氏佐剂免疫Lewis大鼠，观察阿托伐他汀对EAN的影响。结果发现，阿托伐他汀可改善EAN的临床症状，减少坐骨神经中炎性细胞和干扰素-γ(+)、白介素17(+)细胞的数量，减少单个核细胞(MNC)中CD80的表达，增加CD25(+)Foxp3(+)细胞的数量，并降低MNC培养上清液中的干扰素-γ水平。这些数据提供了强有力的证据，表明阿托伐他汀可以通过抑制Th1和Th17的免疫反应，减少共刺激分子的表达，上调T调节细胞的数量，在EAN中发挥抑制作用。这些数据表明，他汀类药物未来可以作为治疗人类GBS的一种策略。(C)2011 Elsevier Inc.保留所有权利。
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain-Barre syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund's adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-gamma(+) and IL-17(+) cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25(+)Foxp3(+) cells in mononuclear cells (MNC), and decreased the levels of IFN-gamma in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future. (C) 2011 Elsevier Inc. All rights reserved.