CD4+ and CD8+ cell cytokine profiles in neonates, older children, and adults:: Increasing T helper type 1 and T cytotoxic type 1 cell populations with age
CD4+ and CD8+ cell cytokine profiles in neonates, older children, and adults:: Increasing T helper type 1 and T cytotoxic type 1 cell populations with age
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DOI：
10.1006/cimm.1998.1244
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发表时间：
1998-02-01
影响因子：
4.3
通讯作者：
Sakurai, M
中科院分区：
文献类型：
--
作者：
Chipeta, J;Komada, Y;Sakurai, M
越来越多的证据表明，在各种人类疾病状态下，辅助性T细胞1型和2型（Th 1/Th 2），包括它们的对应物细胞毒性T细胞1型和2型（Tc 1/Tc 2）细胞应答，需要确定正常T细胞亚群的细胞因子谱。我们在这里显示，使用细胞内细胞因子染色和细胞计数，在健康受试者中，产生干扰素（IFN）-γ的CD 4（+）（Th 1）和CD 8（+）（Tc 1）细胞群随着年龄的增长而逐渐增加，与CD 45 RO表面抗原表达密切相关。与此同时，能够产生IL-4（Th 2和Tc 2）的细胞群在所有年龄组中几乎都是最少的。总的来说，这些结果可能反映了Th 1和Tc 1细胞群从新生儿期到成年期的成熟和扩增，最有可能依赖于抗原暴露。(C)北京：科学出版社.
The growing body of evidence suggestive of T helper types 1 and 2 (Th1/Th2) including their counterparts T cytotoxic types 1 and 2 (Tc1/Tc2) cell responses during various human disease states necessitates determination of normal T cell subsets' cytokine profiles. We show here, using intracellular cytokine staining and how cytometry, that in healthy subjects interferon (IFN)-gamma producing CD4(+) (Th1) and CD8(+) (Tc1) cell populations progressively increase with age with strong correlation to CD45RO surface antigen expression. Meanwhile populations of cells capable of producing IL-4 (Th2 and Tc2) are comparably minimal across all age groups. Collectively, these results may reflect the maturation and expansion of Th1 and Tc1 cell populations from the neonatal period to adulthood, most probably dependent on antigen exposure. (C) 1998 Academic Press.