Label-free electronic detection of DNA using simple double-walled carbon nanotube resistors
Label-free electronic detection of DNA using simple double-walled carbon nanotube resistors
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DOI：
10.1021/jp7121714
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发表时间：
2008-07-03
影响因子：
3.7
通讯作者：
Li, Lain-Jong
中科院分区：
文献类型：
--
作者：
Dong, Xiaochen;Fu, Dongliang;Li, Lain-Jong
提出了基于滴铸双壁碳纳米管（DWNT）网络和生长膜的电阻传感装置的DNA杂交无标记电检测。通过简单的双端测量实现了DNA杂交的敏感，选择性和可靠的检测，这适用于手持式设备应用。我们的方法能够检测DNA浓度范围从50到500 nM。利用光阻剂的位置选择性封盖，我们设计了实验来揭示传感机制，并发现碳纳米管(CNT)-金属结可能不像在单壁碳纳米管晶体管器件中那样在传感中起主导作用。提出了一个电荷转移模型来解释探测机制。
Label-free electrical detection of DNA hybridization using resistive sensing devices based on drop-casted doubled-walled carbon nanotube (DWNT) networks and as-grown films is presented. Sensitive, selective, and reliable detection of DNA hybridization is achieved by simple two-terminal measurements, which is suitable for the hand-held type of device applications. Our approach is able to detect DNA concentrations ranging from 50 to 500 nM. Utilizing location-selective capping by photoresists, we designed experiments to reveal the sensing mechanism and found that the carbon nanotube (CNT)-metal junction may not play a dominant role in sensing as it does in single-walled carbon nanotube-based transistor devices. A charge-transfer model is proposed to explain the detection mechanism.