β1 and β4 integrins: from breast development to clinical practice.
β1 and β4 integrins: from breast development to clinical practice.
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DOI：
10.1186/s13058-014-0459-x
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bissell MJ
中科院分区：
文献类型：
--
作者：
Nisticò P;Di Modugno F;Spada S;Bissell MJ
经过上皮细胞和周围微环境之间高度动态和复杂的对话，乳腺在青春期发育成分支结构，在怀孕期间发育成芽，在哺乳期形成复杂的极腺泡，一旦婴儿断奶，就会重塑和退化。在月经和妊娠周期的每个阶段，细胞和细胞外基质（ECM）之间的相互作用以及同型和异型细胞间相互作用产生了该连接处腺体的结构和功能。如果没有 ECM 受体的重要作用，这些精心策划的计划就不可能实现，整合素就是最好的例子。 ECM-整合素轴调节许多重要的细胞功能，包括生存、迁移和静止；这些过程中任何一个的不平衡都可能导致肿瘤发生。在这篇综述中，我们重点关注两个重要的整合素亚基，β1 和 β4 整合素，与酪氨酸激酶受体的相互作用，我们讨论了这些整合素亚基在正常乳腺分化的生物学中的作用以及作为乳腺癌潜在预后和治疗靶点的作用。本文的在线版本 (doi:10.1186/s13058-014-0459-x) 包含补充材料，可供授权用户使用。
Following a highly dynamic and complex dialogue between the epithelium and the surrounding microenvironment, the mammary gland develops into a branching structure during puberty, buds during pregnancy, forms intricate polar acini during lactation and, once the babies are weaned, remodels and involutes. At every stage of menstrual and pregnancy cycles, interactions between the cells and the extracellular matrix (ECM) and homotypic and heterotypic cell–cell interactions give rise to the architecture and function of the gland at that junction. These orchestrated programs would not be possible without the important role of the ECM receptors, integrins being the prime examples. The ECM–integrin axis regulates many crucial cellular functions including survival, migration and quiescence; the imbalance in any of these processes could contribute to oncogenesis. In this review we spotlight the involvement of two prominent integrin subunits, β1 and β4 integrins, in cross-talk with tyrosine kinase receptors, and we discuss the roles of these integrin subunits in the biology of normal breast differentiation and as potential prognostic and therapeutic targets in breast cancer. The online version of this article (doi:10.1186/s13058-014-0459-x) contains supplementary material, which is available to authorized users.
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影响因子：
4
作者：
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通讯作者：
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DOI：
10.1073/pnas.1214394109
发表时间：
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影响因子：
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作者：
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