HYDROGEN-PEROXIDE AND HYDROXYL FREE-RADICAL PRODUCTION BY HEMATOPORPHYRIN DERIVATIVE, ASCORBATE AND LIGHT
HYDROGEN-PEROXIDE AND HYDROXYL FREE-RADICAL PRODUCTION BY HEMATOPORPHYRIN DERIVATIVE, ASCORBATE AND LIGHT
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DOI：
10.1016/s0304-3835(15)30009-4
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发表时间：
1985-01-01
期刊：
影响因子：
9.7
通讯作者：
NEED, MJ
中科院分区：
文献类型：
--
作者：
BUETTNER, GR;NEED, MJ
PHOTOFRIN II是一种含有高比例活性双血卟啉乙醚的血卟啉衍生物的商业制剂，在抗坏血酸和光的存在下，将O2转化为过氧化氢和羟基自由基。此外，随着抗坏血酸的氧化，在血卟啉衍生物/抗坏血酸溶液中观察到抗坏血酸自由基浓度的光依赖性增加。
Photofrin II, a commercial preparation of a hematoporphyrin derivative containing a high proportion of the active di-hematoporphyrin ether, converted O2 to H2O2 and hydroxyl free radicals in the presence of ascorbate and light. In addition, a light-dependent increase in the ascorbate free radical concentration was observed in hematoporphyrin derivative/ascorbate solutions with subsequent oxidation of ascorbate.