Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science
Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science
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DOI：
10.1016/j.psyneuen.2009.06.017
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发表时间：
2009-11-01
影响因子：
3.7
通讯作者：
Kapelewski, Christine H.
中科院分区：
文献类型：
--
作者：
Granger, Douglas A.;Hibel, Leah C.;Kapelewski, Christine H.
唾液中皮质醇的非侵入性测量使行为科学家能够探索日常生活中自然发生的下丘脑-垂体-肾上腺(HPA)轴的活动、内在因素和社会力量之间的相互作用的关联和伴随。唾液皮质醇与行为科学的广泛结合也表明，日常生活中无处不在的特征，如非处方药和处方药，都有能力影响测量的有效性。我们确定了几种药物影响唾液皮质醇的途径，包括(A)对HPA轴的直接激动性和拮抗性作用，(B)对与HPA轴联网的生理系统的间接影响，(C)通过药物诱导的主观体验的改变对皮质醇分泌的调节或中介作用，(D)医源性对唾液的可用性或成分的影响，或血清成分向口服液的扩散，以及(E)与用于通过免疫分析检测皮质醇的抗体的交叉反应。能够通过这些途径影响唾液皮质醇的特定药物被记录在案，以努力在下一代研究中从程序和统计上最大限度地减少这种潜在的误差来源。(C)2009爱思唯尔有限公司。保留所有权利。
The non-invasive measurement of cortisol in saliva has enabled behavioral scientists to explore the correlates and concomitants of the interaction between the activity of the hypothalamic-pituitary-adrenal (HPA) axis, intrinsic factors, and social forces as they occur naturally in everyday life. The widespread integration of salivary cortisol into behavioral science has also revealed that omnipresent features of everyday life such as, over-the-counter and prescription medications, have the capacity to influence measurement validity. We identify several pathways by which pharmacologic agents could influence salivary cortisol, including (a) direct agonistic and antagonistic effects on the HPA axis, (b) indirect effects on physiological systems networked with the HPA axis, (c) moderation or mediation effects on cortisol secretion via pharmacologically induced change in subjective experience, (d) iatrogenic effects on the availability or composition of saliva, or the diffusion of serum constituents into oral fluid, and (e) cross-reactivities with antibodies used to detect cortisol by immunoassay. Specific medications with the capacity to influence salivary cortisol via these pathways are documented in an effort to procedurally and statistically minimize this potential source of error variance in the next generation of studies. (C) 2009 Elsevier Ltd. All rights reserved.