Opioid receptor genes inactivated in mice:: the highlights
Opioid receptor genes inactivated in mice:: the highlights
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DOI：
10.1054/npep.2002.0900
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发表时间：
2002-04-01
期刊：
影响因子：
2.9
通讯作者：
Kieffer, BL
中科院分区：
文献类型：
--
作者：
Gavériaux-Ruff, C;Kieffer, BL
阿片系统控制伤害感受、应激反应和成瘾行为。外源性生物碱阿片类药物和内源性阿片肽刺激μ-、δ-和κ-阿片受体，其活性长期以来一直通过药理学工具进行分析。现在已经通过基因打靶产生了缺乏阿片受体和阿片肽前体基因的小鼠。在没有药物的情况下对突变动物的行为分析突出了阿片受体或肽在伤害感受中的独特作用，并揭示了δ受体在情感行为中的重要作用。对药物反应的检查已经阐明了每个受体作为外源性阿片类药物在体内的分子靶点的参与。这些数据也证明了μ受体在大麻素和酒精强化中的关键作用，并证实了κ受体参与了几种焦虑反应。因此，正在进行的研究有助于了解阿片类药物控制行为的分子基础，并将有助于开发疼痛，焦虑和药物滥用的新疗法。(C)2002爱思唯尔科技有限公司版权所有。
The opioid system controls nociception, stress responses, and addictive behaviors. Exogenous alkaloid opiates and endogenous opioid peptides stimulate mu-, delta- and kappa-opioid receptors, whose activities have long been analyzed by pharmacological tools. Mice lacking opioid receptor and opioid peptide precursor genes have now been produced by gene targeting. Behavioral analysis of mutant animals in the absence of drug has highlighted a distinct role of opioid receptors or peptides in nociception and revealed an important role for delta receptors in emotional behaviors. The examination of responses to drugs has clarified involvement of each receptor as molecular targets for exogenous opiates in vivo. Those data have also demonstrated the critical role of mu-receptor in cannabinoid and alcohol reinforcement and confirmed the involvement of kappa receptor in several dysphoric responses. Ongoing studies therefore help in understanding the molecular basis of opioid-controlled behaviors and will contribute to the development of novel therapeutics for pain, anxiety, and drug abuse. (C) 2002 Elsevier Science Ltd. All rights reserved.