EFFECT OF IMMATURITY OF CALF ON IMMUNOLOGICAL RESPONSES TO STRAIN-19 AND KILLED 45-20 ADJUVANT VACCINES
EFFECT OF IMMATURITY OF CALF ON IMMUNOLOGICAL RESPONSES TO STRAIN-19 AND KILLED 45-20 ADJUVANT VACCINES
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DOI：
10.1136/vr.101.14.283
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发表时间：
1977-01-01
影响因子：
2.2
通讯作者：
CUNNINGHAM, B
中科院分区：
文献类型：
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作者：
CUNNINGHAM, B
对30头血清凝集试验（SAT）、补体结合试验（CFT）和抗球蛋白试验（ABGT）均为零滴度的无布鲁氏菌病犊牛在7小时至198日龄接种菌株19。75日龄及以上的小牛对正常血清学模式作出反应，对所有三种试验均产生高滴度。在45日龄和更年轻的时候，大多数小牛的反应是滴度大大降低，一些小牛对SAT和CFT呈阴性，但所有小牛都对ABGT产生了滴度。其中两个年轻组在大约一岁时接受了回忆测试，并给出了阳性反应，这表明小牛可能早在出生的第一天就有效地接种了S19。其中三只被剥夺了初乳，但它们的反应模式与初乳喂养的小牛相似。74头零滴度犊牛在60 - 320日龄接种灭活45/20佐剂疫苗。到200日龄，33头小牛中只有7头呈阳性反应。从200到280天，29只小牛中有18只作出了反应，从280天开始，所有小牛都作出了阳性反应。后期开发的能力，以应对这种佐剂疫苗是有点不寻常的，并进行了讨论。初步认为45/20粗毒株在牛中可能是一种很弱的抗原。
Thirty brucellosis free calves with zero titres to the serum agglutination test (SAT), complement fixation test (CFT) and antiglobulin test (ABGT) were vaccinated with strain 19 at ages from seven hours to 198 days. Calves 75 days of age and older responded with normal serological patterns, developing high titres to all three tests. At 45 days and younger most calves responded with much reduced titres, some were negative to the SAT and CFT but all develped titres to the ABGT. Two of the younger group were subjected to an anamnestic test at about a year old and gave a positive response, indicating that the calf may be effectively primed with S19 as early as the first day of life. Three of the group were colostrumdeprived yet the patterns of their responses were similar to those of the colostrum-fed calves. Seventy-four zero titres calves were vaccinated with killed 45/20 adjuvant vaccine at ages from 60 to 320 days. Up to 200 days of age only seven of 33 calves gave positive response. From 200 to 280 days 18 of 29 responded and from 280 days of age all calves a positive response. The late development of competence to respond to this adjuvant vaccine is somewhat unusual and is discussed. It is suggested that the rough strain 45/20 may be a very weak antigen in cattle.