The management of gastrointestinal stromal tumors: a model for targeted and multidisciplinary therapy of malignancy.
The management of gastrointestinal stromal tumors: a model for targeted and multidisciplinary therapy of malignancy.
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胃肠道肿瘤的管理：一种针对性和多学科治疗恶性肿瘤的模型。
DOI：
10.1146/annurev-med-043010-091813
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发表时间：
2012
影响因子：
10.5
通讯作者：
DeMatteo RP
中科院分区：
文献类型：
--
作者：
Joensuu H;DeMatteo RP
胃肠道间质瘤(GIST)已成为肿瘤靶向治疗的模型。绝大多数GIST包含KIT或血小板衍生生长因子A(PDGFRA)基因的激活突变。GIST对几种选择性酪氨酸激酶抑制剂高度敏感。事实上，这种癌症在一些患者中已经转化为慢性病。最近，我们在了解GIST的自然历史和分子生物学、风险分层和耐药性方面取得了相当大的进展。尽管靶向治疗有效，但手术仍然是唯一有效的主要治疗方法，可治愈50%以上出现局部疾病的GIST患者。伊马替尼辅助治疗可延长无复发生存期，并可能提高总生存期。在肿瘤分子分型后，联合或连续使用酪氨酸激酶抑制剂和其他药物是治疗GIST的一个有吸引力的下一步。
Gastrointestinal stromal tumor (GIST) has become a model for targeted therapy in cancer. The vast majority of GISTs contain an activating mutation in either the KIT or platelet-derived growth factor A (PDGFRA) gene. GIST is highly responsive to several selective tyrosine kinase inhibitors. In fact, this cancer has been converted to a chronic disease in some patients. Considerable progress has been made recently in our understanding of the natural history and molecular biology of GIST, risk stratification and drug resistance. Despite the efficacy of targeted therapy, though, surgery remains the only curative primary treatment and cures more than 50% of GIST patients who present with localized disease. Adjuvant therapy with imatinib prolongs recurrence-free survival and may improve overall survival. Combined or sequential use of tyrosine kinase inhibitors with other agents following tumor molecular subtyping is an attractive next step in the management of GIST.
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影响因子：
2.5
作者：
Eisenberg, Burton L.;Harris, Jonathan;Blanke, Charles D.;Demetri, George D.;Heinrich, Michael C.;Watson, James C.;Hoffman, John P.;Okuno, Scott;Kane, John M.;von Mehren, Margaret
通讯作者：
von Mehren, Margaret
影响因子：
3.7
作者：
Agaram, Narasimhan P.;Wong, Grace C.;Guo, Tianhua;Maki, Robert G.;Singer, Samuel;DeMatteo, Ronald P.;Besmer, Peter;Antonescu, Cristina R.
通讯作者：
Antonescu, Cristina R.
影响因子：
45.3
作者：
Choi, Haesun;Charnsangavej, Chuslip;Benjamin, Robert S.
通讯作者：
Benjamin, Robert S.
影响因子：
45.3
作者：
Blay, Jean-Yves;Le Cesne, Axel;Perol, David
通讯作者：
Perol, David
影响因子：
6.2
作者：
DeMatteo, Ronald P.;Gold, Jason S.;Antonescu, Cristina R.
通讯作者：
Antonescu, Cristina R.