Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model
Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model
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DOI：
10.1253/circj.70.206
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Izumi, T
中科院分区：
文献类型：
--
作者：
Sato, D;Niwano, S;Izumi, T
Background The effect of bepridil, a multichannel blocker, on atrial electrical remodeling was evaluated in a canine rapid atrial stimulation model.Methods and Results In 10 beagle dogs, the fight atrial appendage (RAA) was paced at 400 beats/min for 2 weeks. The atrial electrophysiological parameters, including effective refractory period (AERP), were evaluated at three atrial sites: RAA, the right atrium close to the inferior vena cava (IVC) and the left atrium (LA), during the time course of rapid pacing. Five of the dogs were given bepridil (10 mg(.)kg(-1.)day(-1) po). In the control group, AERP was significantly shortened at all atrial sites and the AERP shortening (Delta AERP) was larger for the RAA and LA than at the IVC site (p < 0.05). In the bepridil group, Delta AERP was smaller than that of the controls at all atrial sites, and the AERP started to return slowly to the pre-pacing level in the second week, regardless of the continuation of rapid pacing.Conclusions In a canine rapid atrial stimulation model, bepridil suppressed AERP shortening. Bepridil might have a reverse electrical remodeling effect, at least for AERP shortening, because it showed slow recovery of AERP in the subacute phase of rapid atrial pacing.
